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Exact(5)

What may be the influence of these treatments on the manual performance of the ipsilesional hand within the first few weeks post-lesion (up to 60 days)?

The pre-lesion period was used to establish the manual performance of reference, the average retrieval score and its standard deviation (SD).

A first subgroup of 4 monkeys (Mk-JA, Mk-VA, Mk-BI and Mk-MO) out of 11 showed a small and transient deficit of manual performance of the ipsilesional hand immediately after the lesion of M1 (Table  2).

The possible effects of unilateral motor cortex (M1) lesion on the ipsilesional hand was assessed during a short-term time window ranging from 0 to 60 days post-lesion, by comparing the pre-lesion and post-lesion manual performance of each animal in the Modified Brinkman Board task.

Moreover, deficits in the ipsilesional hand's manual performance during the days following the lesion of M1 did not correlate with the presence or absence of enhancement of manual performance of the ipsilesional hand on the long-term, found in the monkeys which recovered best their manual performance for the contralesional hand (Kaeser et al. 2010).

Similar(55)

For each of the three parameters we assessed, there was, however, a minority of monkeys exhibiting a modest (but statistically significant) deficit of manual performance for the ipsilesional hand, limited to a few days immediately following the lesion.

Despite the possibility of manual, performance degenerating adaptations of the original model, alternative trees are systematically searched.

The present study aims at extending these initial data using: (1) a larger population of monkeys; (2) a more quantitative assessment of manual performance; and (3) lesions whose extent and location are guided electrophysiologically by ICMS.

Considering the monkeys showing deficits of manual performance with the ipsilesional hand for either one or two parameters, there is no obvious correlation with the size and/or the precise position of the lesion (Fig.  1).

As a consequence, the deficit observed in the marmoset for the ipsilesional hand cannot be interpreted as a specific reduction of manual performance, as the lesion spread to more proximal territories in M1, as well as other cortical and subcortical areas.

To the best of our knowledge, the originality of the present study lies in a systematic and quantitative assessment of the manual performance deficit for the ipsilesional hand resulting from unilateral lesion of M1 in non-human primates targeting the hand representation.

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