Sentence examples for manner without causing from inspiring English sources

Hence, to advance this field in a rational manner without causing further environmental damage, we suggest an integrated preventive approach.

In vivo study showed that 17b significantly suppressed tumor growth in a dose-dependent manner without causing the loss of the mean body weight of mice, which was superior to doxorubicin.

Eldecalcitol increased lumbar BMD in a dose-dependent manner without causing hypercalcemia or hypercalciuria.

Oral administration of GM-611 (2.5 10 mg/kg) in normal rabbits produced sustained depolarization of the duodenal smooth muscle and increased stool weight in a dose-dependent manner without causing loose stools.

In a randomized, placebo-controlled, double-blind clinical trial in osteoporotic patients receiving vitamin D supplementation, 12-month treatment with eldecalcitol increased lumbar and hip bone mineral density in a dose-dependent manner, without causing sustained hypercalcemia [ 2].

Similarly, using cultured primary human peripheral blood mononuclear cells (PBMCs) from normal donors, Li et al. [ 64] demonstrated that teriflunomide inhibits proliferation of CpG-stimulated B cells and anti-CD3-stimulated T cells (both CD4+ and CD8+ T cells) in a dose-dependent manner without causing cell death (Fig.  3a c).

Company executives said they faced a need to keep skilled professionals in the business unit, which traded trillions of dollars worth of financial derivatives, because it would take great expertise to shut down the business in an orderly manner and without causing more turmoil.

Transgenic mice harboring the SPAK gene under control of the villin gene utilize the tissue-specific expression of villin in the intestinal epithelium, which facilitates transgenic SPAK expression in a tissue-specific manner [40] without causing unexpected results in other tissues.

Similar results were recently obtained in pre-fontal cortex synaptosomes and hippocampal mossy fiber terminals, where activation of α7 nAChRs by nicotine has been shown to enhance glutamate release in an extracellular Ca2+-dependent and VOCCs-independent manner and without causing membrane depolarization [22], [23].

Incubation of SS RBCs (hematocrit∼ 20%) with TD-1 prior to exposure to hypoxia reduced the percentage of sickled cells without causing hemolysis in a dose-dependent manner.

Importantly, however, treatment with phloroglucinol effectively suppressed the migratory and invasive ability of MDA-MB231 breast cancer cells in a dose-dependent manner (Fig. 1b, c), indicating that phloroglucinol suppresses malignant phenotypes of breast cancer cells without causing cell death.