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Adjuvants (usually bacterial, e.g., Mycobacterium in complete Freund's adjuvant) activate the innate immune response in the same pathogen-specific manner when administered with self-antigen; this process results in organ-specific autoimmune disease in animal models (9, 16 ).
This conclusion is supported by the following four results: (1) e- Baifuzi protected ischemia-induced brain injury in a dose-dependent manner when administered after global or focal cerebral ischemia in rats and mice.
It is now clear that all GLP-1 agonists have the capacity to slow gastric emptying in a variable but often marked manner when administered acutely, although emptying has often been quantified by the suboptimal paracetamol absorption test.
ES interacts with the binding site of PPARα in a similar way as OEA does, is capable of activating PPARα and also reduces feeding in a dose-dependent manner when administered to food-deprived rats.
We reported that IIS reduction protected animals from Aβ1 42 mediated paralysis in a DAF-16 and HSF-1 dependent manner when administered during development and adulthood [ daf-2, daf-16 and hsf-1 RNAi treatments affects neither Aβ expression levels nor the Aβ total protein amounts (Cohen et al., 2006)].
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In BALB/c mice treated for 3 days, DE-71 increased liver weight in a dose-dependent manner only when administered po.
Furthermore, the analgesia seems to follow an indiscriminate manner, for example, when administered intrathecally, RvE1 or RvD1 alleviates both heat and mechanical hypersensitivity.
The result of the analysis of tricin in blood and tissues of mice, which had received the tricin-containing diet, intimates that the systemic bioavailability of tricin might be low when administered in this manner.
However, evidence suggests that well-designed questionnaires provide acceptable data when administered in an appropriate manner [ 50].
In this model of chronic cancer pain, rapamycin was also effective when administered in a therapeutic manner, that is, once daily 5 days after injection of cancer cells within the tibia [ 73].
Indeed, similar to cardiomyogenic differentiation of embryonic stem cells [47], we have identified an effective protocol utilizing key growth factors and cytokines which regulate c-kitpos cCSC cardiomyogenic differentiation resulting in rhythmic contraction when administered in a stage-specific manner to cCSCs in vitro (Ellison et al. Unpublished).
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