Sentence examples for manner to block from inspiring English sources

First, we asked whether expression of the SUMO loss of function SnoN (EdA) mutant might act in a dominantly interfering manner to block the function of the SUMO E3 ligase PIAS1 in NMuMG cells.

These proteins, that may be collectively termed IκB-DR (IκB-degradation resistant, [19], act in a dominant negative manner to block NF-κB activation, by impairing its nuclear translocation and transcriptional activation [20].

Thus, the ancestral α-subunit could have been a slightly stronger antagonist with a higher affinity to the ActRIIB that was able to act in a betaglycan-independent manner to block activin action.

The disordered segments of the 7B2 protein may also function in this manner to block α-synuclein aggregation.

Notably, IGFBP7 has received attention as a potent secreted tumour suppressor acting in an autocrine/paracrine manner to block melanoma genesis (Wajapeyee et al., 2008).

In other patients with morphologically similar leukemias, but without the t(8 21) translocation, heterozygous mutations in C/EBPα result in the production of an amino terminus truncated protein that acts in a dominant negative manner to block C/EBPα DNA binding [ 2].

Of particular significance, the PAR1-selective antagonist, SCH79797, in a concentration-dependent manner, was able to block the proliferative actions of both α-thrombin and TFLLR-NH2.

According to the website, Time Warner has become "a government-regulated near monopoly," and behaved in an anti-American manner when it moved to block Al Jazeera.

Molecules that effectively antagonize soluble Wnt3a protein but are ineffective against the Wnt3a signal presented by a cell in a paracrine or autocrine manner are also unable to block liposomal Wnt3a activity, suggesting that liposomal packaging mimics the biological state of active Wnts.

Although legitimate in theory, the doctrine had been invoked in an unprecedented manner by the Bush administration to block judicial review of a broad range of questionable practices.

Computer experts, however, warn that once installed, the software could be directed to block all manner of content or allow the government to monitor Internet use and collect personal information.