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Advances in our understanding and ability to manipulate stem cell behavior are helping to move stem cell-based therapies toward the clinic.
With an ageing world population it is becoming significantly apparent that there is a need to produce implants and platforms to manipulate stem cell growth on a pharmaceutical scale.
This paper details one of the first ever studies in to the manipulation of stem cell growth on CO2 laser surface treated nylon 6,6 highlighting its potential as an inexpensive platform to manipulate stem cell growth on a pharmaceutical scale.
Identifying genes regulating stem cell properties will greatly improve our understanding of the molecular mechanisms regulating stem cell functions, our ability to manipulate stem cell fate, and the roles of stem cells in cancer.
As the stem cell state space is composed of a set of regulatory states with inter-conversions between them dictated by the network topology, the question arises to what extent knowledge of network wiring may increase our ability to manipulate stem cell fate choices.
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The advance in stem cell research relies largely on the efficiency and biocompatibility of technologies used to manipulate stem cells.
A new non-viral carrier and the cell culture system are described to efficiently manipulate stem cells.
The microwell chip presented here gives the opportunity to monitor and manipulate stem cells in a new way, enabling individual treatment, clonal assays, and maintenance and differentiation studies of stem cells in high throughput.
Stem cell based tissue engineering therapies involve the administration of ex vivo manipulated stem cell populations with the purpose of repairing and regenerating damaged or diseased tissue.
Envisioned restorative bone therapies include, for example, engineered cell scaffolds combined with bone grafts and the delivery of manipulated stem cells including patient-specific induced pluripotent stem cells.
The major advantage of ex vivo gene therapy is that the genetically manipulated stem cells not only secrete osteoinductive growth factors that recruit host osteoprogenitor cells via paracrine signaling (osteoinduction) but also differentiate into osteoblasts via an autocrine mechanism and participate in new bone formation (osteogenic) [ 3, 67, 68].
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