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Conway, A. et al. Multivalent ligands control stem cell behaviour in vitro and in vivo.
Mechanisms of eukaryotic transcription that control stem cell pluripotency, differentiation and disease.
Our laboratory studies the cellular and molecular mechanisms that control stem cell activity and function within epithelia, the tissues that line our internal organs and outer surfaces.
Using these animals, we seek to understand quantitatively the fundamental rules that control stem cell collective behavior to optimize tissue regeneration, remolding, and adaptation.
Whereas chemical signals that control stem cell behavior are increasingly understood, much less is known about the mechanical properties of stem cell niches.
Here, surface nanotopographies and surface-immobilised biosignals have been identified as major factors that control stem cell responses.
Three-dimensional scaffolds that control stem cell fate would be broadly useful for applications in regenerative medicine and tissue engineering.
Recent advances in automated, high-throughput methods for synthesizing and screening combinatorial biomaterial libraries and cellular microenvironments promise to accelerate the discovery of factors that control stem cell behavior.
These synthetic matrices, which comprise of "off-the-shelf" components and are easy to synthesize, provide an ideal tool to elucidate the molecular mechanisms that control stem cell fate.
According to research done by Moving Forward, the percentage of voters who are opposed to a host of issues being hijacked by abortion including birth control, stem cell and sex education are only 9% of the electorate.
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Control stem cell-derived cardiomyocytes had an organized and expanded mitochondrial network necessary for energy supply to developing sarcomeres and excitation-contraction machinery (Fig. 5D left).
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