Used and loved by millions
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com
makes no significant difference
Grammar usage guide and real-world examplesUSAGE SUMMARY
The phrase "makes no significant difference" is correct and usable in written English.
It can be used to indicate that a particular action, change, or factor does not have a meaningful impact on the outcome or situation being discussed. Example: "Whether we start the project now or next week makes no significant difference to the overall timeline."
✓ Grammatically correct
Science
News & Media
Alternative expressions(4)
Table of contents
Usage summary
Human-verified examples
Expert writing tips
Linguistic context
Ludwig's wrap-up
Alternative expressions
FAQs
Human-verified examples from authoritative sources
Exact Expressions
8 human-written examples
We conclude therefore, that in the cases considered here, the image ratio analysis does not produce a physically meaningful value of plasma temperature; in addition, background subtraction makes no significant difference to the temperatures results.
Science
Hence, employing Kr or Xe makes no significant difference in terms of optimizing the radical density at low velocities.
At each step, it adds the most statistically significant term (the one with lowest P value) until the addition of the next variable makes no significant difference.
Some studies of mainstream programs have found that part-time versus full-time provision in any given year makes no significant difference to cognitive gains (Cleveland and Forer 2010; Sylva et al. 2004; Howes et al. 2008).
While satisfaction with teaching makes no significant difference across all three tertiles to completion outcomes at all, the two upper tertiles of satisfaction with assessment imply a mildly increased propensity to complete by about one percentage point.
Whether HMGB1 originates from mammalian cells or is a His-tagged recombinant protein makes no significant difference.
Science
Human-verified similar examples from authoritative sources
Similar Expressions
52 human-written examples
11 However, a larger study from North America and Europe using the Antiretroviral Cohort Collaboration (ART CC) showed that mortality among patients with differing CD4 nadirs made no significant difference once a patient stabilized.
But if we stopped buying oil from those nations tomorrow — stopped cold — it would make no significant difference in their income.
News & Media
In a 2002 study, the National Research Council, which functions under the National Academy of Sciences, found that DARE made no significant difference in drug use among students.
News & Media
Several studies led by Dr. Joan Teno, a geriatrician at the University of Washington who has often collaborated with Dr. Mitchell, show that they make no significant difference.
News & Media
The presence of lines joining the data points made no significant difference to the risk of false negative responses (Table 2).
Science & Research
Expert writing Tips
Best practice
When using "makes no significant difference", ensure that the context clearly establishes the parameters within which the difference is being evaluated. Specify what is not significantly different and in relation to what.
Common error
Avoid using "makes no significant difference" when there is a slight, but still measurable, impact. The phrase implies a negligible effect, so ensure this aligns with the actual data or observation.
Source & Trust
83%
Authority and reliability
4.5/5
Expert rating
Real-world application tested
Linguistic Context
The phrase "makes no significant difference" primarily functions as a declarative statement expressing the lack of a meaningful impact or effect. As Ludwig AI states, the phrase is deemed grammatically correct and usable in written English.
Frequent in
Science
80%
News & Media
16%
Formal & Business
4%
Less common in
Encyclopedias
0%
Wiki
0%
Reference
0%
Ludwig's WRAP-UP
The phrase "makes no significant difference" is a grammatically sound expression used to denote the absence of a substantial impact. Ludwig AI confirms its correctness and usability in English writing. While appearing most frequently in scientific contexts, it maintains a neutral tone suitable for diverse applications. When using this phrase, ensure clarity in specifying what lacks a significant difference and relative to what. Alternatives include "has no major impact", "doesn't substantially alter", and "is inconsequential".
More alternative expressions(6)
Phrases that express similar concepts, ordered by semantic similarity:
has no major impact
Focuses on the lack of a substantial effect.
doesn't substantially alter
Emphasizes the absence of a significant change.
has little bearing on
Highlights the minimal relevance or influence.
doesn't materially affect
Stresses the lack of a tangible impact.
is of little consequence
Indicates that the matter is not important or impactful.
amounts to the same thing
Highlights the equivalence of outcomes.
is essentially the same
Focuses on the similarity despite potential variations.
has no appreciable effect
Emphasizes the lack of noticeable impact.
changes nothing of substance
Indicates no meaningful change.
is inconsequential
Highlights the unimportance of something.
FAQs
What does "makes no significant difference" mean?
The phrase "makes no significant difference" means that a particular factor, action, or change does not have a substantial or meaningful impact on the outcome or situation being considered.
How can I use "makes no significant difference" in a sentence?
You can use "makes no significant difference" to indicate that altering a variable does not substantially affect the result. For example: "Whether you choose option A or B "makes no significant difference" to the final cost."
What are some alternatives to "makes no significant difference"?
Alternatives to "makes no significant difference" include "has no major impact", "doesn't substantially alter", or "is inconsequential".
Is it grammatically correct to say "makes no significant difference"?
Yes, the phrase "makes no significant difference" is grammatically correct and commonly used in both formal and informal contexts.
Editing plus AI, all in one place.
Stop switching between tools. Your AI writing partner for everything—polishing proposals, crafting emails, finding the right tone.
Table of contents
Usage summary
Human-verified examples
Expert writing tips
Linguistic context
Ludwig's wrap-up
Alternative expressions
FAQs
Source & Trust
83%
Authority and reliability
4.5/5
Expert rating
Real-world application tested