Sentence examples for major stimulus of from inspiring English sources

Although TGFβ is not increased in SSc plasma, multiple studies have strongly implicated this cytokine as a major stimulus of fibrosis in involved organs.

The latter one is a major stimulus of VEGF synthesis and provides a substantial role in the immune defence in the wound [ 46].

It has therefore been suggested that the direct interaction of activated T cells with monocytes, rather than the T cell-based production of cytokines, is a major stimulus of the excessive levels of TNF-α and IL-1β in RA.

The major stimulus of CRP synthesis is interleukin 6 (IL6; Goldman & Liu 1987, Li & Goldman 1996), which is also responsible for the recruitment of monocytes during chronic inflammation and therefore plays an important role in the transition from acute to chronic inflammation (Gabay 2006).

The task was a three-stimulus auditory odd-ball task, target stimuli were the major stimuli of interest.

Apart from growth factors, proinflammatory cytokines are the major stimuli of changes in metabolism of RASFs.

Although bacterial endotoxins such as lipopolysaccharide (LPS) and other microbial products are major stimuli of monocyte activation in infectious diseases, they are not considered to be relevant stimuli in autoimmune settings.

One of the major stimuli of cancer angiogenesis is hypoxia, which activates hypoxia-inducible transcription factors (HIFs), which in turn induce the expression of VEGF, VEGFR, bFGF, and PDGF.

In a physiological state, IL-6 plays a role in neuropoiesis and neurogenesis [ 20, 21], whereas under pathophysiological conditions, it is one of the major stimuli of neuroinflammatory response [ 17, 22– 22].

Motion is one of the major stimuli on visual attention of dynamic scene.

Not only have we identified CD8+ T cells as dominant cellular sources of IFNγ in lupus patients, but we have also importantly discovered that CD8+ T cells are the major stimulus for induction of IDO in UC-MSCs.