Sentence examples for major population stratification from inspiring English sources

The estimated inflation factor for genomic control of λ = 1.045, calculated by analysing 61 unlinked genetic markers, did not reveal a major population stratification in our study group.

We therefore prefer to use the representative PCs in Equation (41) for removing the main variations caused by major population stratification, while keeping the variations due to subtle subpopulation structures unchanged.

The results of our population structure analyses are consistent with no major population stratification present in this sample of the Spanish population.

No major population stratification between KORA Southwestt Germany) and two other cohorts from Northern Germany could be detected in an intensive study using a genomic control approach [ 12].

With respect to yet genotyped markers neither major population stratification between the whole KORA sample (southwest Germany) or two other cohorts from Northern Germany [ 51] nor deviations in the Minor Allele Frequencies (MAFs) to those of the HapMap Ceu Population could be detected.

This should rule out any major influence of population stratification.

Artificial insemination and genetic selection are major factors contributing to population stratification in dairy cattle.

Genetic selection and artificial insemination are major factors contributing to population stratification in dairy cattle.

Even if some major systematic errors (e.g. population stratification, genotyping error, phenotype misclassification) are controlled, not all biases are foreseeable.

To assess whether population stratification was a major concern in our study, the median of the Armitage's trend test statistics of 61 unlinked biallelic markers (see Supplementary Table S1) was analysed to estimate the inflation factor λ for genomic control [29].

Population stratification is another major challenge in interpreting GWAS.