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"major population center" is a correct and usable phrase in written English.
It is typically used to refer to a large and significant city or urban area where a significant portion of a country's population reside. Example: New York City is considered a major population center in the United States, with over 8 million residents and a constant influx of tourists and immigrants.
Exact(45)
We consider the problem of designating hazardous materials routes in and through a major population center.
The Philippines, for instance, required cellular operators to extend their digital service to every major population center.
Mered's network in Tripoli was linked to recruiters and logisticians in virtually every major population center in East Africa.
Such an arsenal is literally overkill, sufficient to destroy every major population center on the planet outside of our borders.
On the other hand, if it can intercept one or a few missiles from striking a major population center, many lives would be saved.
And unlike some coastal areas to the north in Oregon, the southwestern coast, however stunning, is several hours from any major population center, much less an affluent one.
Similar(15)
But it changed course, traveling up Cuba's sparsely populated eastern coast and sidestepping major population centers.
Securing the major population centers first.
These plants should not be located near major population centers.
But he couldn't quite overcome Clinton's advantage in the major population centers.
There are no major population centers here; Los Angeles is 3 1 / 2 hours south.
More suggestions(15)
large population center
major community center
greatest population center
major population centered
major population centres
major revenue center
major railroad center
major league center
major population movement
major training center
major population decline
major population change
major crime center
major population strip
major pilgrimage center
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com