Sentence examples for major limit to from inspiring English sources

As single particle cryo-electron microscopy has evolved to a new era of atomic resolution, sample heterogeneity still imposes a major limit to the resolution of many macromolecular complexes, especially those with continuous conformational flexibility.

One major limit to identify sustainable groundwater yield is the lack of a unified evaluation criterion because there are many factors involved in hydrological systems that are difficult to quantify.

We concluded that, in NSCLC, TIL cytotoxicity is likely to be low because of a poor class I MHC expression by tumor cells, and TAM low production of cytotoxic cytokines is a major limit to their possible cytotoxic activity.

With few exceptions, the major limit to high-dose chemotherapeutic treatments is the severity and duration of drug-induced myelosuppression.

Given that KPS was originally developed for people with cancer and had been extrapolated to other clinical settings (AIDS, end-stage organ failure), this should not be a major limit to generalizing these findings.

Materials and methods: Of note, one of the major limits to the use of Ad vector vaccines based on human Ad serotype 5 (huAd5) is the presence of widespread pre-existing immunity in humans.

In this paper, a rigid body moment rotation mechanism is postulated that is based on established shear-friction and partial-interaction research; it is shown to give reasonable correlation with test results as well as incorporating and quantifying the three major limits to rotation of concrete crushing and reinforcing bar fracture and debonding.

There are still major limits to what data studios can access.

One of the major limits to the knowledge of marine biodiversity in this region is the shortage of taxonomic expertise.

Regardless of the approach used, taxonomic expertise was a need, and this has been one of the major limits to knowledge.

The possible unreliability of cues guiding the plastic response is one of the major limits to the benefits of plasticity, although the exploration of costs and limits of phenotypic plasticity is very limited compared to investigations of benefits (DeWitt et al. 1998).