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Mutations clustered in two major geographic groups, one including only Western countries, the other Asia and parts of Europe.
For trials performed exclusively within one of the five major geographic groups, those performed outside high-income regions enrolled significantly more participants than trials in the high-income group.
Similarly, there were no trends in the percentage of trials performed exclusively within non-high-income major geographic groups, although there was some fluctuation in rates, especially for the Americas and Asia (Fig. 4b).
Countries were geographically classified according to the categorization used in the Global Burden of Disease project which classifies countries into 21 regions and these regions into five major geographic groups (Fig. 1), available at http://ghdx.healthdata.org/country_profiles [ 23].
Among the major geographic groups, Europe (non-Western) had the highest rate of collaboration with the high-income regions, with 91.3 % of trials conducted having a high-income collaborating site, while trials with sites in Asia had the lowest rate, with 57.9 % of trials including a site in a high-income region.
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Descriptive analyses were performed quantifying study sites and trials and describing trial characteristics by region and major geographic group.
Here, we presented an analysis based on new PAX9 exon 3 sequence information and its exon-intron border regions from Native American, African, and Eskimo populations, which were integrated with published information encompassing all major human geographic groups.
As the full complexity of ape evolution is beyond this review, I characterize major geographic, temporal, and phylogenetic groups using a few flagship taxa.
10.7554/eLife.04395.015 Figure 8. Numbers of airline passengers arriving from at-risk countries to other countries stratified by major geographic regions and national income groups.
Tested groups corresponded to major geographic regions [ 16, 30- 32].
For subsequent hierarchical analyses, the 53 populations were grouped into the 5 major geographic regions defined by Rosenberg et al. [ 7, 26]: Africa, Eurasia, East Asia, Oceania, and America.
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