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Genetic predisposition is indicated by familial cases and ethnic differences in incidence rates but the increasing trend and major geographic differences in incidence are consistent with environmental influence.
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However, there is widespread inconsistency among the associated DTNPB1 haplotypes with a variety of combinations of SNPs and risk alleles reported throughout the literature [ 82], complicated even more by large genetic differences between major geographic populations [ 19, 24].
In addition to the geographic differences, the demographic breakdown was significantly different from the original district.
Since at least the 1700s, scholars have argued that geographic differences such as rainfall, air temperature, and soil quality can have a major impact on economic development.
Striking geographic differences and changes in cancer incidence over time have led epidemiologists to infer that probably the major etiologic component is environmental.
Croatia is composed of three major geographic regions.
Nevertheless, al-Idrīsī's book is a major geographic monument.
Two major geographic boundaries separate North Carolina's provinces.
There are geographic differences, but again nothing to stir the blood.
The Yorkshire Post has previously revealed the huge geographic differences in funding from Arts Council England.
The final report acknowledges that "some socioeconomic, racial, ethnic and geographic differences exist".
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