We previously described 3 major genetic subgroups of Qataris, including those of Bedouin (Q1), Persian-South Asian (Q2), and African ancestry (Q3) [ 2– 4].
Analyses of recurrent patterns of somatically acquired DNA copy number alterations resulted in the delineation of three major genetic subgroups with predictive tumour behaviour (subtype 1, 2A and 2B), of which subtype 2A NB represents an aggressive subgroup of metastatic NB [ 5, 6] characterised by loss of 11q, gain of 17q and a normal MYCN copy number status [ 6].
Cytogenetics, fluorescence in situ hybridization (FISH) and molecular studies (RT-PCR, qRT-PCR and qMSP) were used to characterize 58 acute myeloid leukemia patients (AML) at diagnosis selected to represent the major AML genetic subgroups: CBFB-MYH11 (n = 13), PML-RARA (n = 12); RUnX1-RUNX1T1 (n = 12), normal karyotype (n = 11), and MLL gene fusions other than MLL-SEPT2 (n = 10).
In this work we quantified MLL and SEPT2 gene expression in 58 acute myeloid leukemia patients selected to represent the major AML genetic subgroups, as well as in all three cases of MLL-SEPT2-associated myeloid neoplasms so far described in the literature.
We studied 58 acute myeloid leukemia patients (AML) at diagnosis selected to represent the major AML genetic subgroups, including 13 cases with a CBFB-MYH11 rearrangement, 12 cases with a PML-RARA rearrangement, 12 cases with a RUNX1-RUNX1T1 rearrangement, 11 cases with normal karyotype, and 10 cases with rearrangements of the MLL gene other than MLL-SEPT2 [see Additional file 1].
Chi-square statistic between genetic subgroups and two major traditional species groups, O. rufipogon and O. niva.ra. Figure S6.
Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2 6 possible genotypes within the subgroups.
Through whole-genome sequencing and canonical single-nucleotide polymorphism (canSNP) genotyping, F. tularensis subsp. holarctica has been divided into 4 major genetic groups (B.4, B.6, B.12, and B.16) consisting of multiple subgroups (1 – 3 ).
Sequence analysis of several isolates has identified 2 major genetic lineages (subtypes A and B) that can be divided into subgroups A1, A2, B1, and B2 (6, 7 ).
Phylogenetic analysis of both the F and G gene nucleotide sequences also showed 2 major genetic groups (A and B) that could be further divided into 2 subgroups (1 and 2).
"But the myth of major genetic differences across 'races' is nonetheless worth dismissing with genetic evidence".
