Sentence examples for major clearance pathway from inspiring English sources

Erythropoietin (EPO) receptor-mediated endocytosis and degradation in the bone marrow has been hypothesized to be the major clearance pathway of erythropoiesis-stimulating agents (ESA).

Because only the parent compound binds to the estrogen receptor, conjugation is a detoxification mechanism that represents the major clearance pathway for BPA.

It is possible that the perivascular drainage of Aβ, a major clearance pathway of Aβ from the brain [ 34], was affected in our HHcy mice.

Our results indicated that (1) intratumorally injected HCuSNPs-CpG can be cleared from the local injection site (tumor); (2) hepatobiliary excretion is the major clearance pathway of HCuSNPs-CpG from the body; (3) laser-triggered disintegration of HCuSNPs facilitates particle elimination.

CYP2D6 was identified as the major clearance pathway of LY2878735, resulting in large exposure variability, indicating that CYP2D6 genotyping is insufficient to drive a competitive benefit risk balance for LY2878735, providing an early yet compelling basis for the termination of its current scope of development.

On theoretical grounds, such interactions were not predicted, as the major clearance pathways of saracatinib, carboplatin and paclitaxel are different.

The biodistribution characteristics of our probe were studied 2 h post-injection and demonstrated a rapid clearance in the urine which is a favourable clearance pathway.

Previous reports have shown Aβ clearance pathway alterations with age.

The main clearance pathway for organelle turnover in cells is the autophagic pathway.

Know the major clearance cycles.

Protein clearance pathways provide an opportunity to stimulate clearance of tau and Aβ deposits.