Sentence examples for major checkpoint in from inspiring English sources

The regulation of mRNA translation is a major checkpoint in the flux of information from the transcriptome to the proteome.

Our study establishes Cav1 as a major checkpoint in the transition of MCs and ECs from an epithelial toward a mesenchymal identity.

Impact Our study establishes Cav1 as a major checkpoint in the transition from an epithelial toward a mesenchymal identity in the peritoneum.

It should be stated that there is a major checkpoint in the G2/M phase of the cell cycle where cells arrested in the G2/M phase can undergo apoptosis if optimal conditions are not met (Kastan and Bartek, 2004).

The results presented here provide confidence that sequence specificities for a number of those important enzymes can be inferred in a highly efficient manner; this may in turn significantly contribute to the understanding of transcription initiation that provides a major checkpoint in gene expression regulation.

The mitochondria are one of the major checkpoints in apoptotic regulation because they serve as sensors and amplifiers of cellular damage (Green and Kroemer, 2004).

A series of studies indicate that critical tumor suppressors such as p53 and ARF are major checkpoints in suppressing induced pluripotency [ 108].

Cells deficient for Mec1p, the yeast ATR equivalent and the major checkpoint kinase in yeast, have a very modest decrease in telomere length (Ritchie et al. 1999).

The major checkpoint proteins in mitosis consist of Mad1 3, Bub1, Bub3, and monopolar spindle 1 (Mps1) [14], [15], [15].

Thus, we conclude that the concerted effort of both major checkpoint kinases in fission yeast, Chk1 and Cds1, protect cells from cisplatin induced DNA damage.

The major checkpoint proteins in mitosis consist of mitotic arrest-deficient (Mad)1 3, budding uninhibited by benzimidazole (Bub 1, Bub3, and monopolar spindle 1 Mps1).