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We also considered relative contraindications to, and complications from, anticoagulation therapy, such as major bleeding that required hospitalization.
There were six major access site complications caused by major bleeding that required transfusion and were treated either surgically (in 3 cases) or by a conservative approach.
Some patients suffer from major bleeding that requires immediate attention [ 8], while other patients with ITP present with few symptoms apart from an increased tendency to bruise or have mucosal bleeding.
36 We will not identify the major bleeding that causes a fall in haemoglobin level of at least 20 g/L but does not require a transfusion, 37 because no data on haemoglobin for the patients during follow-up are available in this study.
The reduced risk of major bleeding that had been observed at the 110-mg dose of dabigatran for the collective population was no longer evident compared with the warfarin population that had high periods of time in therapeutic range (>72.6%%) (HR 0.90, 95%% CI 0.67 1.21) [ 21].
Similar(55)
We plan to use the same health state descriptions for stroke and major bleed that we used in a previous study [ 12], which in turn were modified from Man-Son-Hing et al [ 25].
The work leads to the promising concept that it should be possible to develop allosteric inhibitors that reduce clotting, but do not completely eliminate it, thereby avoiding major bleeding complications that beset anticoagulants today.
The most frequent definition for major bleeding was bleeding that was fatal or overt bleeding with a drop in haemoglobin level of at least 20 g/L or requiring transfusion of at least 2 units packed blood cells, or haemorrhage into a critical anatomical site (e.g. intracranial, retroperitoneal).
Second, our assessment of risk factors for DVT and major bleeding suggests that these outcomes were a consequence of comorbidities.
But they also reported that 24 study patients on rivaroxaban subsequently had major bleeding — the kind that can require surgical intervention — compared with 13 who had injections.
All non-major bleedings that require any medical or surgical intervention will be classified as 'clinically relevant non-major bleeding'.
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