Sentence examples for major biotransformation from inspiring English sources

Demethylation, hydroxylation, oxidation and morpholine ring opening were the major biotransformation processes for the phase-I metabolism, while phase-II metabolites were merely generated by the glucuronide conjugation reaction.

Glucuronidation is a major biotransformation pathway for a wide variety of xenobiotics and drugs, and its induction results in increased excretion of d-glucaric acid (Brewster 1988).

Analytical HPLC analysis indicated the appearance of two major biotransformation products (retention times of 9.9 min for compound A and 5.1 min for compound B).

The major biotransformation product of CJM 126 in MCF-710 μM 126cells was 2- 4-aminophenyl -6-hydroxybenzothiazole (6-OH 12- 4-aminophenyl -6-hydroxybenzothiazole

Previously, we reported that a sulfate metabolite was a major biotransformation product of PCB3 applied in vivo via i.p. injection to male Sprague Dawley rats.

After structure annotation, quantification experiments were performed with a Q-TOF instrument in order to study the kinetics of the metabolism of parent toxins and their major biotransformation products.

The prediction of the reacting atom(s) in a molecule for the major classes of biotransformation reactions is necessary to generate drug metabolites.

The purpose of our study is to investigate the possibility of identifying the reacting atoms for the major classes of biotransformation reactions mediated by five human isoforms of cytochrome P450 and by all isoforms of the UDP-glucuronosyltransferase family.

Sulfonation is a major phase II biotransformation reaction.

Such physiological phenomena present a major disadvantage for biotransformation of biomass hydrolysates, which routinely contain various monosaccharides.

Drug-metabolizing enzymes, especially monooxygenases, play a major role in biotransformation and detoxification of many foreign compounds including environmental carcinogens.