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Streptococcus mutans is well documented as a major aetiological agent of dental caries.
Porphyromonas gingivalis (P. gingivalis) is a major aetiological agent associated with periodontitis, a chronic inflammatory disease affecting tooth-supporting tissues.
Hepatitis C virus (HCV) is a major aetiological agent of chronic hepatitis and it leads to the development of liver cirrhosis and hepatocellular carcinoma (HCC).
Noroviruses are the major aetiological agent of endemic gastroenteritis in all age groups, as well as the cause of periodic epidemic gastroenteritis.
Human papillomavirus (HPV) is a major aetiological agent in anal carcinomas.
Although UV radiation is generally considered to be the major aetiological agent, it was found that approximately 75% of the tumours occurred on the relatively unexposed body sites.
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Acute undifferentiated diarrhoea in young calves (neonatal calf diarrhoea) is a daily occurrence all over the world, and rotavirus, Cryptosporidium parvum and coronavirus are major aetiological agents.
However, C. albicans is also an opportunistic pathogen and one of the major aetiological agents of mucosal and systemic fungal infection (Brown et al., 2012).
It is apparent that a number of findings challenge the assumption that bacteria are the major aetiological factor in preterm delivery.
Obesity-induced insulin resistance is a major aetiological factor in the pathogenesis of type 2 diabetes mellitus.
Helicobacter pylori is believed to be the major aetiological factor in the development of non-cardia gastric adenocarcinoma.
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