Sentence examples for maintenance of spines from inspiring English sources

Together, this indicates a dual role of APP for spine structure: an early requirement of APP at stages of spine formation/maturation and also for the maintenance of spines during aging.

The potency of ProSAP/Shank proteins to alter the morphology of the postsynaptic compartment has also been shown by Roussignol et al (2005), who demonstrated that ProSAP2/Shank3 is essential for the maintenance of spines and synapses in hippocampal cultures.

One of these, known as Cdc42, has been shown to promote the formation and maintenance of spines in cell culture, but its role in synaptic plasticity, learning and memory remains unknown.

By monitoring the dynamics of dendritic spines of hippocampal neurons expressing an shRNA vector directed to DGKζ, the authors found that DGKζ is required for the maintenance of spines, but not their formation.

However, during the postnatal period, Cdc42 activity may be functionally restricted to manage activity-dependent changes of actin dynamics that governs aspects of synaptic plasticity rather than gross maintenance of spines.

Its role herein has been mostly studied in HeLa cells, while in neurons, ARF6 was shown to participate in spine morphogenesis, where its activation by the guanine nucleotide exchange factor (GEF), EFA6A (Sakagami, 2008), promoted formation and maintenance of spines in a Rac1-dependent manner (Choi et al, 2006).

Spine-associated Rap guanosine triphosphatase-activating protein (SPAR) is an important regulator of activity-dependent remodeling of synapses and is critically involved in both mature dendritic spine formation and the maintenance of spine maturity.

srGAP3 controls the early stages of dendritic spine formation in an F-BAR domain dependent manner and is dispensable for the maintenance of spine density [ 180].

RanBP9 is a ligand for Rho-GEF, and as Rho-GEF's are known to regulate dendritic and spine morphology, RanBP9 is also naturally expected to have a critical role in the maintenance of spine and dendritic morphology.

Maintenance of spine stability, through decreasing excessive or abnormal spinal movement, is the rationale for many commonly used treatments ranging from 'lumbar stabilization' rehabilitation to spinal fusion surgery [ 1].

Comparing these results suggest that although Camk2a-Cre drives the loss of floxed alleles in both regions, Cdc42 signaling is specifically involved in rapid time-scale spine morphing/maintaining processes during the neuronal activation but, unlike Arp2/3, it is not strongly involved in the long-term maintenance of spine morphology in mature neurons.