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Diubiquitin is involved in the maintenance of spindle integrity during mitosis and is highly upregulated in human HCC [27]; it was detected mostly in the cytoplasm of hepatocytes in the tumors of Mdr2-KO/HCV-Tg mice, and, to a lesser degree, in non-tumorous liver tissues of Mdr2-KO mice with or without the HCV transgene (Fig. 6).
XlKlp2 is required for centrosome separation and maintenance of spindle bipolarity [ 54] whereas PAKRP associates with the phragmoplast [ 39] and is expected to function in cytokinesis.
For example, mutations in Drosophila KLP61F, a Kinesin-5 ortholog, have been shown to disrupt maintenance of spindle pole separation [ 31].
In cell extracts and in cultured cells, two RHAMM mitotic functions have been described: maintenance of spindle integrity (Groen et al., 2004; Joukov et al., 2006; Maxwell et al., 2005) and spindle orientation (Dunsch et al., 2012).
Our results (see ref. 17) clearly indicated that the first requirements of MAST/Orbit were in the normal congression of chromosomes into the metaphase plate and in the maintenance of spindle bipolarity, which contributed for a mitotic delay and eventual abnormal mitotic slippage without chromosome segregation and cytokinesis.
Similar(55)
Overexpressed Bub3 evidently inhibited the homologous chromosome segregation, indicating that Bub3 is involved in monitoring the MI-AI transition, which is similar to a previous report firstly showing Xenopus Bub3 requirement for spindle checkpoint activation and for maintenance of the spindle checkpoint signal [50].
On the machine level, the approaches include avoiding unnecessary stopping and restarting of the spindle, shortening the acceleration time, lightweight design, proper use and maintenance of the spindle.
In particular these two proteins play an essential role in the maintenance of proper spindle length and orientation probably through anchoring the minus end of the mitotic spindles to the centrosome.
To evaluate the efficiency of slush nitrogen vitrification of human oocytes with or without cumulus cells in terms of survival rate and maintenance of meiotic spindle.
However, MAPK activity has other functions during the meiotic cell cycle, including maintenance of meiotic spindle structure [14], [47], [50].
Involvement in MT-binding and spindle checkpoint recruitment also appears to have been conserved from yeast to humans although hSPC105 is more prominent in both activities (e.g., recruitment versus maintenance of the spindle checkpoint).
Related(20)
maintenance of stem
maintenance of tree
maintenance of speed
maintenance of rod
maintenance of axis
maintenance of spine
maintenance of time
conservation of spindle
maintenance of plant
maintenance of user
maintenance of board
maintenance of railway
maintenance of oxygenation
maintenance of health
maintenance of stability
maintenance of effort
maintenance of storage
maintenance of infrastructure
maintenance of certification
maintenance of power
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