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On the contrary, Xenopus laevis oocytes are easily procured in large quantities and have been long used to study meiosis thanks to the conservation of spindle assembly pathways between vertebrate species.
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The conservation of muscle spindle feedback circuits across mammals suggests that the same mechanisms may facilitate motor control in humans.
In the case of spindle positioning, conservation of involvement of PAR and heterotrimeric G proteins suggests a common transduction mechanism between these pathways.
Finally, we compare the BUB1B network with that of its yeast counterpart, MAD3, and discuss the conservation of the human and yeast spindle checkpoints.
These results suggest further conservation for the role of GSK-3 in the regulation of spindle dynamics during mitosis, but also reveal differences in the mechanisms ensuring accurate chromosome segregation.
Lists, illustrations and the significance of spindle count on Windsor chairs.
Zeng, X. et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.
The effects of spindle error motion, spindle unbalance induced eccentricity, thermal error and position drift of AAL are analyzed.
It was composed of spindle cells mainly.
Time zero is initiation of spindle rotation.
To probe how spindle length and shape is set during spindle elongation, we analyzed the dynamics of spindle geometry formation.
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