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In the present open label study, not subsidized by the manufacturer, the investigators prospectively evaluated the acute and maintenance efficacy of pregabalin as an adjunctive medication for a group of treatment refractory outpatients with BD.
The clinical evaluation for maintenance efficacy of the treatments during the follow-up period was the final results.
To explore the necessity of maintenance, efficacy of low-dose and superiority of various combination therapies of Bacillus Calmette-Guérin (BCG) in treatment of superficial bladder cancer (BCa).
Patients who entered ULTRA 3 from either ULTRA 1 or ULTRA 2 (including patients who were randomized to placebo at lead-in study baseline), with the exception of four patients from GCP-noncompliant sites (ADA Extension Set, N=588), were analyzed to evaluate the maintenance efficacy of adalimumab from week 0 to week 156 of ULTRA 3, which corresponds to week 208 from lead-in study baseline.
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5 In ACCENT II, patients were included based on a minimal duration of fistula activity; only patients who responded to initial induction therapy were included in the analysis of maintenance efficacy.
In this phase 3 extension study, the long-term maintenance of efficacy of lisdexamfetamine dimesylate (LDX) in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) was evaluated using a randomized-withdrawal study design.
The maintenance of efficacy of abatacept therapy on other clinical end points will be described in full in another report.
Patients with FM who completed either of the two phase 3, placebo-controlled, double-blind, 14-week trials (studies 06 008 [ 32] and 06 009 [ 33]) evaluating the efficacy and safety of SXB 4.5 g/night and SXB 6 g/night were eligible to enroll in this open-label extension study designed to assess the long-term safety and maintenance of efficacy of SXB.
With the aim of evaluating the long-term maintenance of efficacy of LDX, the subsequent study, SPD489-326, comprised open-label LDX treatment for at least 26 weeks with subsequent randomization to continue on LDX or witreatment placebo for 6 weeks under double-blind conditions [ 9].
The purpose of this report is to evaluate the maintenance of efficacy and tolerability of etoricoxib over 52 weeks of treatment.
Small molecule inhibitors designed to target signaling pathways regulating stem cell renewal and maintenance may increase efficacy of traditional therapies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com