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It is known that normal tissue homeostasis is maintained by dynamic interactions between cells.
Whether interconvertible lineage primed, or pre-patterned substates of pluripotent stem cells are maintained by dynamic gene regulatory networks, or by epigenetic factors, or a combination of both, the observation that stem cells can oscillate between such states should be incorporated into our understanding of cell differentiation during embryogenesis.
These findings suggest that a stable Cse4 nucleosome is maintained by dynamic chaperone-in-residence Scm3.
The structure and homeostasis of normal breast parenchyma is maintained by dynamic interactions between breast epithelial cells and their associated stroma.
As the constitutive heterochromatin is not completely inaccessible to molecules and is maintained by dynamic processes [ 63- 66], the continuous presence of a high level of trans-activators might eventually compete with heterochromatic factors and gain access to binding sites on the hCD2 transgene to activate hCD2 expression [ 67].
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Bone homeostasis is maintained by a dynamic balance between osteoblastic bone formation and osteoclastic bone resorption.
Thus, the identity of a gene expression program is achieved and maintained by the dynamic interplay between specific enhanceosomes and specific local chromatin structure.
Normal skin architecture and melanocyte function is maintained by a dynamic interplay between the melanocytes themselves, the epithelial cells between which they are interspersed, and their microenvironment.
As discussed above, FRAP experiments confirm that apparently stable polarized peaks are indeed maintained by very dynamic recycling of the Cdc42, Bem1, and Cdc24.
While the core histones are bound relatively tightly to DNA, chromatin is largely maintained by the dynamic association with its architectural proteins (such as transcription cofactors and regulators, heterochromatin protein 1, and high mobility group (HMG) proteins).
In conclusion, our findings suggest that during DENV infections endothelial barrier homeostasis is maintained by a dynamic balance between pro-inflammatory/pro-angiogenic cytokines, and type I IFN-dependent CD73 expression and activity.
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