Sentence examples for maintain proteostasis in from inspiring English sources

Additional quantitative studies will be necessary to understand this phenomenon, and to define how different degradative pathways collaborate to establish and maintain proteostasis in specific tissues.

Therefore, developing novel targets and classes of therapeutic drugs, which can reduce aggregates and maintain proteostasis in the brains of neurodegenerative models, is vital.

This is part of a wider integrated physiological response to maintain proteostasis in the face of ER stress, the dysregulation of which is increasingly associated with a wide range of diseases, particularly neurodegenerative disorders.

Our observation that wild-type animals, with fully functional HIF-1, cannot maintain proteostasis in 1000 ppm O2 (Fig. 1B) suggests that hif-1 is not sufficient to prevent the disruption of proteostasis in these conditions, in contrast to the situation in 5000 ppm O2 (Fig. 4B).

Upregulation of the other proteolytic systems is sufficient to maintain proteostasis in a context of defective CMA under basal conditions, but not in the face of different stressors that would typically drive CMA activity such as proteotoxic, lipotoxic, or hepatotoxic agents in vivo.

The unfolded protein response (UPR) is classically responsible for maintaining proteostasis in the secretory pathway by defining levels of chaperones and quality control proteins.

We expect further investigations of the mechanisms through which CysC accumulates and maintains proteostasis in motor neurons should clarify the role of Bunina bodies in ALS.

Upon CMA compromise, the accumulating levels of macroautophagy and proteasomal effectors could lead to the observed enhanced activity of these pathways and allow hepatocytes to maintain proteostasis even in the absence of CMA.

While each system possesses qualities that are unique, it is imperative that they act in a cooperative manner to maintain proteostasis.

By preventing aggregation, promoting folding, and regulating degradation, Hsp70s are major factors in the ability of cells to maintain proteostasis.

These data suggest that, in particular, old cells depend on BAG3 to maintain proteostasis, and that BAG3 knockdown provoked a general stress response, including Hsp and SQSTM1 induction, exclusively in old cells.