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The dominant negative EGFP-Rac1(N17) is mainly localised at the cell membrane and is concentrated in areas of cell-cell contacts.
The PZHPV-7 showed the global faintest fluorescence (mainly localised at nuclear level) with respect to the cancer cells, in agreement with the western blotting data.
Previous studies based on Cep126 transfection have indicated that it is mainly localised at the centrosome and the midbody (Chen et al., 2009; Tipton et al., 2012).
The staining was mainly localised at the basolateral plasma membranes of the surface epithelial cells, whereas the ademomatous and carcinomatous tissue showed faint, patchy staining of the epithelial strands of tumor tissue.
Histological sections of lungs from control mice showed large confluent metastases invading the entire pulmonary tissue and emerging at the surface of the lung while for SR 25989 treated mice the metastases remained significantly smaller and mainly localised at the pulmonary surface.
Similar(55)
We could show that in normal pancreatic tissue, ALCAM is predominantly expressed at the cellular membrane, whereas in pancreatic tumour cells, it is mainly localised in the cytoplasm.
We found that AKT1 and AKT2 were mainly localised in the cytoplasm and nucleus, respectively.
Finally, natural resins (identified as shellac and a Pinaceae resin) were mainly localised in the superficial layers.
The thalamus of both species contained comparatively few immunoreactive fibres, which were mainly localised around the midline.
They are mainly localised close to scratches caused by polishing and they appear to be flat and thin, since the underlying pattern remains visible.
GFP-fusions of CCT, ECT and CK were found in the cytosol whereas the GFP-CEPT mainly localised in the endoplasmic reticulum.
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Justyna Jupowicz-Kozak
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