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In the KB-CP1 cells, FBP induced by DAC was largely localised at the cell surface, explaining the increased uptake of MTX and FA under these conditions.
FBP was largely localised at the cell surface in the KB-CP1 cells after DAC activation, while the protein was mostly found in a Golgi-like distribution inside the cell in the KB-CP20 cells treated with DAC, explaining why this increased expression did not result in increased uptake of methotrexate and FA.
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The current evidence for the synapto-nuclear translocation model shows that transcription regulators, which were previously considered to be largely localised in close proximity to the nucleus, may also be present at remote sites from the nucleus, in postsynaptic dendritic compartments.
William's feast day is celebrated on 8 June, the day of his death, although his veneration is largely localised to York.
The apoptotic chondrocytes were largely localised in the DZ of AC but also observed in the tidemark [ 22].
As tBRD-1 proteins largely localised to Fibrillarin-deficient regions within the nucleolus this might argue against a role of tBRD-1 for ribosomal RNA processing.
In another study, MSCs labelled with In-oxine were shown to be largely localised in pulmonary capillaries and survived only transiently [ 51].
TNF-alpha was expressed focally in 50% of the tumours studied, being largely localised to macrophage-like cells in the stroma.
It can be noted that β2M was found largely localised in the cytoplasm of both tumour samples and the adjacent non-tumour tissues.
U1-70K protein might largely localise directly to speckles, without passage through CBs and nucleoli, which may indicate an additional role for this protein apart from being a U1 snRNP component involved in pre-mRNA splicing.
I think it's high time the government genuinely localised at least a portion of business rates.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com