Three main groups of regulatory interactions are observed: Within the first group are genes affected by U0126 interrupting the activity of MAP2K1/2 and Ly294002 inhibiting PI3K.
Intermolecular interactions represent the main regulatory machinery of a wide variety of biological processes such as signal transduction, cell cell communication, catalysis, as well as metabolism and hormone regulation.
SpotXplore's main contribution is the hotspot-based visualization approach, which enables interactive exploration of regulatory interactions in differentially expressed gene sets, allowing a researcher to explore gene expression in direct relation to the affected cellular gene network.
Functional studies suggest that the main regulatory role of Hxk2 is produced by interaction with the transcriptional repressor Mig1 and the Snf1 protein kinase to generate a repressor complex in the nucleus [ 7, 8].
Furthermore, the main regulatory region (HS1-6) shows the well-known interaction with the β-globin genes and HS1 at the 3′end of the locus in fetal liver cells but not in brain [ 16, 20].
NEI interaction has been acknowledged as the main regulatory component in host's homeostasis since it was put forward in 1977 [ 24].
Overexpression of AtHb1 directly or indirectly perturbed the strong multiple interactions of the hub gene FLA13, shifting the main regulatory point to ATPRP2.
