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Structurally, RXRα is composed of three main functional domains: an N-terminal transcriptional activation function (AF-1) region, a DNA-binding domain and a ligand-binding domain (LBD).
A new mRNA targeting contrast agent consisting of three main functional domains, (i) gadolinium based magnetic resonance reporter part, (ii) antisense peptide nucleic acids targeted to mRNA, and (iii) cholesterol as the delivery vector, was developed and synthesized.
The novel, immunity redirecting biomolecule (AVEC: anti-HER-2 x HbsAg) contains main functional domains: anti-HER-2 antibody (which contains epithelial growth factor receptor 2 (HER-2) targeting, antibody constant fragment receptor (FcR) binding, and C1q component of the complement docking (CD) domains; HBsAg, which is the virus like particle (VLP) of human hepatitis B virus (HBV VLP) (Fig. 1).
The main functional domains in the protein were displayed and analyzed.
Although linearly scattered, these sites were concentrated in the three-dimensional structure of GroEL around three main functional domains.
Sequence alignment revealed high similarity between the three zebrafish Mi-2 homologs, with the main functional domains being conserved (see Additional file 1: Figure S1).
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In this study the Arabidopsis GTS1 ligand-binding domain (main functional domain) lies mainly on the top surface residues, which integrates parts of β-propeller domain.
Domain architecture was considered as conserved ("d" in Fig. 1) if the main functional domain(s) existing in the human and fly proteins were present and showed similar arrangement.
Since there are no sequence gaps upstream of this locus where that exon might be located, this copy is partial, with a likely disruption of the main functional domain.
We then examine the distribution of the main functional V-H+PPase domain on the tree using Protein family (Pfam) database definitions.
Fig. 2 Hypothetical primary structure of a leonardite humic acid Fig. 3 Main functional groups and structural domains, able to complex metals.
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