loss of functions

USAGE SUMMARY

The phrase "loss of functions" is correct and usable in written English.
It can be used in contexts related to biology, medicine, or technology to describe the inability of a system or organism to perform its normal activities. Example: "The patient experienced a significant loss of functions in the affected limb after the injury."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

45 human-written examples

Loss of functions seems to occur across all functional classes of products, but a striking number of transposases, transport proteins and proteins associated with the cell envelope are included in this list.

BMC Genomics

Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear.

Princeton University

Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear.

Princeton University

Duchenne muscle dystrophy (DMD) is a muscular disorder characterized by progressive muscle weakness, resulting in loss of functions.

Neuromuscular Disorders

Mice carrying transgenes targeted upstream the HoxD cluster display abnormal digits, with alterations resembling those obtained with loss of functions of Hoxd genes.

Developmental Biology

Such loss of functions would result in reduced ability of DJ-1 to protect from oxidative stress insults and may lead to increased progression of disease.

Biochimica et Biophysica Acta (BBA) - General Subjects

Human-verified similar examples from authoritative sources

Similar Expressions

15 human-written examples

These conclusions are based on gain- and loss-of functions approaches using H9c2 cardiomyocytes, where we characterize the phenotypes associated with hypertrophied signaling and incorporate the functions of Anxa6 in the hypertrophic process.

Cell Death and Disease

These indicate that p57 was the only cell cycle factor whose expression was confirmed to be regulated positively and negatively by the gain- and loss-of-functions of C/EBPβ, respectively.

Plosone

The present results using Akt1-null materials confirmed a previous report by Fujita et al. that gain- and loss-of-functions of PI3K/Akt signaling regulate the DNA binding and transactivity of Runx2 in cultures of osteoblastic cells [27].

Plosone

This rescue is rather dramatic and demonstrates a strong genetic interaction between rasl11b and oep but it is also remarkable because mutants or loss-of-functions with suppressor abilities have not often been described in zebrafish [63], [64].

Plosone

Finally, the luciferase reporter analysis disclosed that the regulations of Runx2-dependent transcription by gain- and loss-of-functions of GSK-3β, i.e., suppression by CA-GSK-3β overexpression and enhancement by lithium chloride, were cancelled by the S369-S373-S377 mutation (Fig. 4H).

Plosone

Expert writing Tips

Best practice

When discussing "loss of functions" in a scientific context, clearly specify which functions are affected and provide measurable data to support your claims.

Common error

Avoid using "loss of functions" as a vague term. Instead, be specific about which functions are lost (e.g., "loss of motor functions in the left arm" rather than simply "loss of functions").

Linguistic Context

The phrase "loss of functions" functions as a noun phrase, typically serving as the subject or object of a sentence. Ludwig's examples show it describing a decline or absence of capabilities, often in medical or biological contexts.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, the phrase "loss of functions" is a grammatically sound and frequently used term, particularly within scientific and medical fields, to denote a decline or absence of specific abilities. Ludwig AI indicates its correct usage and provides numerous examples illustrating its application in describing biological processes, disease outcomes, and the effects of genetic mutations. While generally formal and scientific in register, it is crucial to specify the functions affected rather than using it as a vague, overgeneralized term. Alternatives like "functional decline" or "impairment of function" may be suitable depending on the context.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

functional decline

Focuses on the process of losing functionality over time.

impairment of function

Emphasizes the reduced ability to perform specific tasks.

functional impairment

Similar to "impairment of function", but slightly broader in scope.

decreased functionality

Highlights the reduction in the level of function.

decline in functionality

Focuses on the degradation of functional abilities.

functional deficit

Indicates a specific lack or shortage of function.

loss of capability

Focuses on the inability to perform certain actions.

dysfunction

Refers to abnormal or impaired function.

compromised function

Suggests that the function is weakened or at risk.

reduced capacity

Emphasizes the diminished ability to perform tasks effectively.

FAQs

How can I use "loss of functions" in a sentence?

You can use "loss of functions" to describe a decline in the ability to perform specific tasks or activities, as in "The disease led to a significant "loss of functions" in the patient's lower limbs".

What are some alternatives to "loss of functions"?

Some alternatives include "functional decline", "impairment of function", or "decreased functionality", depending on the specific context.

Is it more appropriate to say "loss of function" or "loss of functions"?

"Loss of function" generally refers to the loss of a single, specific function, while "loss of functions" refers to the loss of multiple functions. The choice depends on whether you're discussing one specific function or several.

What causes "loss of functions"?

"Loss of functions" can be caused by a variety of factors, including aging, disease, injury, or genetic mutations. The specific cause will depend on the context in which the phrase is used.