loss of complement

USAGE SUMMARY

The phrase "loss of complement" is correct and usable in written English.
It can be used in contexts related to linguistics, biology, or other fields where the term "complement" has specific meanings, often referring to something that completes or enhances another element. Example: "The study focused on the loss of complement in the immune response, which can lead to increased susceptibility to infections."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

3 human-written examples

For example, proteinuria (and renal loss of complement) may represent a separate mechanism for risk of infection than uraemia.

BMJ Open

Recent studies suggested that neural degeneration in glaucoma was also related to immune system [ 60– 62], and they pointed out that the loss of complement activity in both acquired and innate immune process was involved in RGCs damage [ 63, 64].

BMC Ophthalmology

Figure  5A (bottom) confirmed the loss of complement activity in rat serum in this protocol, as shown using an in vitro CDC assay in which AQP4-expressing CHO cells were incubated with NMO-IgG and rat serum.

Acta neuropathologica communications

Human-verified similar examples from authoritative sources

Similar Expressions

56 human-written examples

In addition to genetic loss-of-function, we complemented our analysis by treating embryos with the Shh/Gli activator pur.

BMC Genomics

However, detectable systemic C5a suggests a loss of regulation of complement activation.

Plosone

Killing of two or more consecutive, early cohorts of GPT neurons (36 81% losses of original complement), with minimum delays of 24 h for settlement of replacements, yields the catastrophic outcome of groups in the severe ablation cluster.

ASN Neuro

Deficiency Df 2R w45-30n lacks regions 45A-45E, theremovingoving the pkn gene and fails to complement loss-of-function pkn alleles such as pkn 06736, pkn, and pkn.

G3: Genes, Genomes, Genetics

Loss of tolerance to complement factors is one of the mechanisms that results in an autoimmune disease such as atypical haemolytic uraemic syndrome (aHUS).

Autoimmunity Highlights

Accordingly, it has recently been suggested that loss of synapses via complement may play a role in glaucoma [29].

Plosone

Therefore we conclude that the polyclonal hypergammaglobulinaemia which leads to a decrease in the level of capsular specific IgG against pneumococcus does not result in a loss of function in complement deposition on S. pneumoniae.

Plosone

The subtle developmental phenotypes observed in ces-1 plants suggested that CES loss-of-function might be complemented by functional homologues.

EMBO Journal

Expert writing Tips

Best practice

When discussing immunological or disease-related topics, use "loss of complement" precisely to indicate a reduction or absence of complement proteins or activity. Ensure the context clearly defines whether this is a general phenomenon or specific to a particular condition or experimental setup.

Common error

Avoid using "loss of complement" interchangeably with general immune deficiencies. "Loss of complement" specifically refers to issues related to the complement system, while other deficiencies may involve different components of the immune system. Be precise in your terminology.

Linguistic Context

The phrase "loss of complement" functions primarily as a noun phrase. It typically serves as the subject or object of a sentence, describing a state or condition. It identifies a specific deficiency in the immune system, as evidenced by its use in scientific literature (Ludwig).

Expression frequency: Rare

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Encyclopedias

0%

Ludwig's WRAP-UP

In summary, "loss of complement" is a term primarily used in scientific and medical contexts to describe a deficiency or reduction in the complement system's function. Ludwig AI confirms that this phrase is grammatically sound and appropriate for describing specific immunological conditions. While it's a relatively rare phrase, it's important to use it accurately and avoid confusing it with other types of immune deficiencies. Alternative phrases like "complement depletion" or "complement deficiency" can be used depending on the specific context. Understanding its specific meaning is crucial for precise communication in scientific and medical fields.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

complement depletion

Focuses on the reduction of complement components.

complement deficiency

Indicates a lack or inadequacy of complement.

impaired complement activity

Highlights the reduced functionality of the complement system.

dysfunctional complement system

Emphasizes that the complement system is not working correctly.

complement inactivation

Suggests the complement system has been rendered inactive.

reduced complement levels

Focuses on the measurable decrease in the quantity of complement proteins.

compromised complement function

Highlights the impaired ability of the complement system to perform its role.

complement system failure

Indicates a complete breakdown in the complement system's operation.

attenuated complement response

Describes a weakened or diminished response from the complement system.

decreased complement effectiveness

Focuses on the reduced ability of the complement system to achieve its intended effect.

FAQs

How does "loss of complement" affect the immune system?

"Loss of complement" can compromise the immune system's ability to fight infections, clear immune complexes, and regulate inflammation. The complement system plays a crucial role in both innate and adaptive immunity, so its deficiency can lead to increased susceptibility to various diseases.

What are some potential causes of "loss of complement"?

"Loss of complement" can be caused by genetic defects, autoimmune diseases, or certain infections. Genetic mutations can lead to deficiencies in specific complement proteins, while autoimmune diseases can result in excessive consumption or inactivation of complement components. Certain infections can also trigger complement dysregulation.

What can I say instead of "loss of complement"?

You can use alternatives like "complement depletion", "complement deficiency", or "impaired complement activity", depending on the specific context and nuance you want to convey.

Is "loss of complement" always a negative occurrence?

In most contexts, "loss of complement" is associated with negative outcomes, such as increased susceptibility to infections or autoimmune diseases. However, in certain experimental or therapeutic settings, controlled complement inhibition might be desirable to mitigate excessive inflammation or tissue damage. Therefore, the effect of "loss of complement" depends on the specific context.