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We decided it was important to examine the effect of such infections on DR, because if they account for the lifespan difference, it is unlikely DR in Drosophila is useful as a model for higher organisms.
The mechanism underlying this lifespan difference is currently not clear.
We next analyzed whether there was a sex-based lifespan difference.
The high R (all 24 equations, 12 for MAX and 12 for MIN, was >0.90) suggests a strong relationship between radiant energy at MAX and MIN and the lifespan difference between diabetics and non-diabetics.
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First, we show that there are lifespan differences between D. americana populations from different regions of the distribution range.
Similarly, lifespan differences have been reported due to the use of different bacterial strains as food for Caenorhabditis elegans [13] or by interchanging casein and soy peptone as the source of dietary protein for rodents [14].
To gain further insight into the lifespan differences observed between males and females, as well as, when comparing different populations, D. americana individuals with the typical X/ 4 fusion, Xc, 4ab, and 5b inversions (strain O57) and individuals without these chromosomal rearrangements, and thus with inversion 5a (see Introduction; strain W29), have been crossed in both directions.
Postmortem studies indicate that iron content and lifespan differences therein are regionally specific, with a predilection for the basal ganglia.
Comparative genomics and linkage analysis identify candidate genes associated with lifespan differences between various turquoise killifish strains.
Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive.
This susceptibility to heart attacks, heart failure and other heart conditions is likely at the root of lifespan differences.
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Justyna Jupowicz-Kozak
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