In contrast, upregulation of levels of WISP-1 mRNA was observed in 50 of 60 (83%) NSCLC samples in comparison with their normal tissues (Fig. 1).
In contrast, levels of WISP-1 in cancers were significantly higher than those in the matched normal ones (P<0.001) (Table 1).
The expression levels of WISP-1, in mammary tumours from Wnt-1 transgenic mice, were high in stromal fibroblasts lying within the fibrovascular tumour stroma, but low focally within tumour cells (Pennica et al, 1998).
Elevated levels of WISP-1 in primary breast cancer were associated with more advanced features, such as tumour size and metastases to axillary lymph nodes (Xie et al, 2001).
Level of WISP-1 in ASC was much higher than those in either SC (P = 0.002) or AC (P = 0.015).
Moreover, younger patients (ages, 35 50) had a significantly higher level of WISP-1 in their tumors than older individuals (ages, 50 65 or ≥65) (P = 0.018 and P = 0.036, respectively).
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The expression levels of PAI-2, WISP-1 and UG measured by RTQ PCR were similar to those measured by the microarrays.
