Your English writing platform
Discover LudwigExact(1)
The application of a wide range of different diffraction and spectroscopy techniques [7] [14] has helped to elucidate various aspects of fibril architecture and has confirmed molecular polymorphism on several structural levels of filament organization [6], [12], [15] [17].
Similar(58)
Our results further suggest that the hierarchical makeup of IFs is elementary in defining their characteristic mechanical properties through a cascaded activation of deformation mechanisms, each associated with a specific level of filament strain as shown in Table 1.
This suggests that TRF2 does not inhibit Rad51 at the level of filament formation.
According to our qPCR result, when exogenous TGF-β (10 ng/ml) was added, the mRNA levels of fibrotic filament Acta2 and ECM mediators Col I-α1 and Fn1 in LTC-14 cells were up-regulated by roughly 3 to 6 folds.
Firstly, the degree of filament bending due to the curvature of the cell membrane in vivo is tiny at the level of subunit interfaces and much smaller than the bent filaments that have been observed by EM.
Minimal gold particles were observed in regions of the neuron with low levels of tau filaments (Fig. 3c).
Germ cell-specific or Sertoli cell-specific deletion of Aip1 gene each led to significant defects in germ cell migration after postnatal day 4 or 5, accompanied by elevated levels of actin filaments (F-actin) in the affected cells.
At the ensemble level, movements of filaments integrate into a net retrograde flow of ∼138 nm/min.
A high vimentin score indicates a high level of intermediate filament disassembly.
Lastly, we also show that changes in the expression levels of the intermediate filament proteins GFAP (glial fibrillary acidic protein) and S100B are affected by Aβ-induced calcium changes differently, with GFAP being more dependent on calcium levels than S100B.
During filament formation, there are counter-acting forces, such as decrease in entropy and possible structural adjustment at the pore-lining surface of the CARD filament, which would increase the energy level of the filaments.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com