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In glioblastoma, the landmark phase III trial by the European Organisation for Research and Treatment of Cancer and the National Cancer Institute of Canada has defined the current standard of care.
In the landmark phase III study 50% of the patients required a dose reduction of sunitinib due to these events (Motzer et al, 2008a, 2008b).
Long-term outcomes 7 8 years after initiation of intensive ranibizumab therapy were assessed in patients originally treated with ranibizumab in landmark phase 3 trials (SEVEN-UP).
28 A subsequent landmark phase II trial of ofatumumab in fludarabine and alemtuzumab-refractory patients demonstrated an ORR of 47% 58% in both groups, with the most common adverse events being grade 1 2 infections or infusion reactions.
In a recently published landmark phase III trial of cisplatin plus gemcitabine versus gemcitabine alone for the treatment of BTC, no complete responses were seen among 117 gallbladder cancer patients treated [ 3].
8– 13, 14, 14 In a landmark Phase III trial that assessed the efficacy of bevacizumab alone or in combination with irinotecan in recurrent glioblastoma, HTN was more frequent in the bevacizumab alone arm.
Similar(43)
In the landmark based phase, landmarks are chosen from the pathological image and macro image and match them in a similar way to the connection step.
In 2006, results were reported from a landmark, randomized phase III trial of HNSCC patients with locally advanced disease that compared cetuximab plus radiation to radiation alone [26].
In April it passed a landmark law phasing in a minimum retirement age.
The early work put emphasis on the experimental methods as thermal analysis and metallographic and resulted in the landmark collection of phase diagrams.
This week, the G7 leaders convened in a Bavarian castle and announced a landmark commitment to phase out fossil fuels by 2100.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com