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We applied an aerobic, growth-arrested and high-density cell reaction to the shikimate production by the resulting strain and notably achieved the highest shikimate titer (141 g/l) and a yield (51% (mol/mol)) from glucose reported to date after 48 h in minimal medium lacking nutrients required for cell growth.
"Two billion people have hidden hunger," he said, meaning they are able to find something to eat but it may be scanty and may consist of poor quality food lacking nutrients and protein.
Lacking nutrients and energy, a malnourished child is more susceptible to illnesses – making it more complicated for treatment and recovery.
Although it has been initially thought that autophagy would contribute to cell death, recent evidence suggests that autophagy is mostly a cytoprotective mechanism that allow cells to mobilize their energy reserves and to recycle damaged organelles in conditions of lacking nutrients, hypoxia, endoplasmic reticulum stress, accumulation of misfolded proteins, or DNA damage.
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Re-addition of the lacking nutrient triggers exit from stationary phase and sudden activation of the PKA pathway, the latter being mediated by the nutrient transceptors.
Re-addition of the lacking nutrient triggers rapid reversal to a high-PKA phenotype and one of the earliest read-outs is activation of the PKA phosphorylation target trehalase (Hirimburegama et al. 1992; Schepers et al. 2012).
It lacks nutrients.
Access to cheap, processed food that lacks nutrients is a real issue.
Some residents are suspicious of the water, saying its purity means it lacks nutrients.
So far, the EthioSIS project has analysed more than 80% of our agricultural soils, revealing that they lack nutrients such as potassium, sulphur, zinc, boron and copper.
The issue is even more of a concern during humanitarian crises, when food supplies are at a critically low level and people are likely to lack nutrients and be more susceptible to disease.
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