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Exact(5)
Furthermore, re-introduction of ectopically expressed bid (Fig. 1 D) was able to re-sensitize this clone to Fas-induced caspase activation and apoptosis (Fig. 1 E), indicating that the reduction in caspase activity after death receptor activation was due to the lack of Bid expression.
Our investigation suggests that lack of Bid cleavage might contribute to the failure of caspase-9 activation.
Absence of Bim almost completely abrogated anti-Fas antibody-induced hepatitis, and synergized with lack of Bid in protecting from TNF- α-mediated liver damage.
NPCs appear to express full-length Bid, thus, the lack of Bid cleavage suggests that caspase-8 is not efficiently activated by TNF α in NPCs although the reason for this is not clear.
The missing activation of the caspase-9 pathway may result from an impaired 'cross talk' with the caspase-8 pathway because of the lack of Bid cleavage and from the appearance of as XIAP cleavage product known to inhibit caspase-9 activation.
Similar(54)
And their lack of bidding discussion nearly caused a disaster on the diagramed deal.
Because the price is in line with others in the building, Mr. Mitchell was mystified by the lack of bids.
A goal of €2.6bn had been set for 2013 but the lack of bids for Depa signals that even that modest target might be unachievable.
HEARTLAND itself has revised its method of valuing these bonds to reflect, Mr. Nasgovitz said, "credit quality concerns, lack of market makers, lack of bids" and trading in similar bonds.
The similarities include a lack of competing bids, lots of political posturing and restless shareholders.
But experts who have seen the report pointed to a number of flaws, including a lack of competitive bidding, nonstakeholder participation, lapses in procurement procedures, and missing documentation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com