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SVMs are trained with a database of known soluble and insoluble compounds, and this information is being exploited afterwards to improve Virtual Screening (VS) prediction.

We describe a new approach to the problem, where we use molecular dynamics (MD) simulations to find the differences between the untractable protein and the known soluble VH domain from a llama antibody.

However, our understanding of the structures and functions of membrane proteins has lagged behind the known soluble proteins.

However, our understanding of structures and functions of the membrane proteins lag far behind the known soluble proteins.

The ErbB2 receptor has no known soluble ligand (Holbro et al, 2003b).

Subjecting the conditioned media to an angiogenesis antibody array, we revealed that PHD2 consistently regulates angiogenin (ANG) and IL-8, two known soluble pro-angiogenic factors.

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Similar(51)

The soluble form, which is known as soluble mesothelin-related protein or soluble mesothelin-related peptide (SMRP), has emerged as a potential biomarker for the early detection of asbestos-induced mesothelioma [ 88, 89].

Soluble fms-like tyrosine kinase 1 (sFlt-1), also known as soluble vascular endothelial growth factor (VEGF) receptor1 is an anti-angiogenic protein that is increased prior to the onset of the clinical disease in women with pre-eclampsia.

Circulating angiogenic factors, such as soluble vascular endothelial growth factor Type 1 receptor (also known as soluble Fms-like tyrosine kinase 1, sFlt1) are suggested to contribute to the development of the disease [ 162].

Although a previous publication has shown the involvement of TNFR2 in modulating cPLA2 activity, it is known that soluble TNF-α is inefficient in activating TNFR2, and hence treatment with soluble TNF-α will mainly activate TNFR1.

Specifically, a soluble fraction of Toxoplasma gondii tachyzoites contains a potent inducer for IL-12 known as soluble Toxoplasma antigen (STAg), which is recognized and of which the active component is a profilin-like molecule that is known to function as an actin-binding protein and implicated in parasite motility or invasion.

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