Sentence examples for understood soluble from inspiring English sources

Although the precise mechanism is poorly understood, soluble Nef has been shown to enter M Φ.

Although the underlying mechanisms for HAND pathogenesis are not fully understood, soluble factors including HIV-1 viral products and pro-inflammatory mediators released from the infected glia and monocytes have been implicated (Ghafouri et al., 2006; King et al., 2006; Wallace 2006; Ances and Ellis, 2007).

The function of these different splice variants is still poorly understood, but soluble DR-3 should buffer the action of TL1A.

Collectively, it is of great significance to understand how soluble Aβ, insoluble amyloid plaques and hyperphosphorylated tau accumulation contribute to synaptic loss in AD.

In order to understand what soluble factors may be responsible for the observed differences to CD137 ligand signaling between the B cells and MM cells, we next investigated which cytokines if any were expressed.

To understand if soluble factors have any role in the diminution of NK cell cytotoxicity, we compared cell-free supernatants from MSC cultures and NK-MSC contact cultures for their NK cells suppressive ability.

To understand the soluble factors involved in the observed activity, the aCD4 supernatants (aCD4S) were screened for the presence of 13 common Th1 and Th2 pro-inflammatory and anti-inflammatory cytokines as described in materials and methods, and were found to contain various concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-13, IFN-γ, TNF-α and GM-CSF (data not shown).

These events are coordinated by a sophisticated and as yet, not understood language of soluble mediators involving cytokines, chemokines and growth factors.

The downstream mediators for most receptor systems, either membrane-bound or soluble, are fairly well understood.

In contrast to soluble proteins, little is understood about the structure and folding of membrane-related proteins.

Although these modulatory effects are partially understood, direct cell-to-cell contact and soluble factors are relevant [90].