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Exact(7)
At the same time, the RNA shows a bigger diversity in the types of interacting base pairs [9] and employs both the canonical and non-canonical base pairs, which results in a rich variety of the secondary and tertiary structures of the RNA.
Therefore, we also include simulated data based on substitution statistics of interacting base pairs.
For calculating the ED-values, we must know the first and the last interacting base in both sequences.
Hence, in the complete lack of covariation, PETcofold reduces to an improved energy folding approach, which also has impact on matching up the interacting base pairs.
The definitions are We counted true positives (TPs), false positives (FPs) and false negatives (FNs) by comparing the verified interacting base pairs with predicted ones.
In order to estimate accuracy of the programs, we measure the sensitivity, PPV and F-measure such that only interacting base pairs are considered.
Similar(52)
In contrast, the regions we tested and that scored to be interacting based on the 4C data indeed had interaction frequencies significantly above the background (>9%; p<0.001, G-test), both in untreated and α-amanitin treated cells.
In an attempt to validate our hypothesis that pairs of genes showing excess genetic divergence represent potential functional interactions, we selected a small set of gene combinations postulated to be interacting based on our analyses and looked for a combined effect of the selected genes on variation in complex traits in both mice and man.
We let S2ij represent the event that domain pair dij is interacting based on the occurrence of dij in Prdp.
Feature S1ij represents the event that domain pair dij is interacting based on the expected frequency of occurrence estimated from a given set of protein pairs.
A simple function of RDPij is used to simulate a probability density function for the probability of dij interacting based on information about its occurrence in Rosetta stone proteins.
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