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We found high variability in linezolid serum concentrations with mostly insufficient low levels in critically ill patients.
The strength of the body of evidence rating (ie, insufficient, low, moderate, or high level of evidence) was based on the consensus of all team investigators.
These numbers resulted in a sufficient, high positive predictive value (79%; 95% confidence interval 49-95%), but an insufficient, low sensitivity (38%; 95% confidence interval 21-58%).
Moreover, the R of 0.087 indicates an insufficient low communality for the factor representing the facet death and dying but with an estimate of 0.257.
The high variability of linezolid levels found in our study, with a substantial proportion at insufficient low levels, might contribute to the observed high mortality rate and severity of infection in ICU patients.
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Contrast this with digital media: Small audiences, insufficient stickiness, low monetisation plague both web sites and mobile apps; the advertising model for digital information is mostly a failure – and that's not Google's fault.
In the others, it was partly sufficient or insufficient implying low power and high risk to achieve insignificant outcomes.
Besides, one of our principles is to generate random sequences on the GPU since NVIDIA SDK Mersenne Twister proved to be insufficient at low numbers.
However, this strategy faces many challenges, including instability in the gastrointestinal (GI) tract, insufficient bioavailability, low tumor targeting, and severe adverse effects.
But the present devices are not ideal enough to meet the application needs because the problems of insufficient capture, low purity, and narrow detection spectrum still need to be addressed.
Conventional PDT efficacy is restricted by insufficient selectivity, low solubility of photosensitizers, and limited penetration depth of the 630-nm laser light, which reduces the PDT efficacy for tumors located in deeper tissues compared with those at the body surface.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com