in close linkage

USAGE SUMMARY

The phrase "in close linkage" is correct and usable in written English.
It can be used to describe a strong connection or relationship between two or more elements, often in academic or technical contexts. Example: "The study found that the two variables are in close linkage, suggesting a significant correlation between them."

✓ Grammatically correct

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

36 human-written examples

The m2 mutations were in close linkage disequilibrium with the m1 mutations; 53% m1 mutants had the mutation in the m2 site.

Cancer Epidemiology

Just a few days earlier the two scientific teams that have deciphered the chemical sequences of the human genome presented their first detailed analyses, making it clear that humans have evolved in close linkage with other species.

The New York Times

The first near-Sun interplanetary measurements together with concurrent remote observations of the Sun will permit us to determine and understand, through correlative studies, the characteristics of the solar wind and energetic particles in close linkage with the plasma and radiation conditions in their source regions on the Sun.

Advances in Space Research

Surprisingly, none of the sixteen candidate genes was in close linkage with the locus controlling the carbonaria-typical polymorphism.

Plosone

This approach was taken to limit potential bias from SNPs in close linkage disequilibrium and to measure of variability of Fst.

Plosone

Besides identifying a real causative polymorphism directly responsible for the phenotype, allelic association may point to a polymorphism that is in close linkage disequilibrium to the associated marker.

Plosone

Human-verified similar examples from authoritative sources

Similar Expressions

24 human-written examples

The strongly conserved LD we observed across the QTL on chromosomes C02 and C09 was found to be associated with a large number of functionally related genes in close genetic linkage.

BMC Genomics

Even when in close proximity, disulfide linkage between two neighboring cysteines is extremely slow and requires electron acceptors20,21.

Nature

We think pleiotropy is unlikely for the variants that we used to generate the CRP haplotypes as they are in very close linkage disequilibrium with variation within a putative transcription factor binding site located 5' of the CRP gene that has been associated with circulating concentrations of CRP and thought to be functional [43], [44].

Plosone

Strictly, the analysis can only reject pleiotropy in favour of close linkage and not the other way around since linkage between adjacent genes is not likely to be broken.

BMC Genomics

Analysis of the functional class II region in zebrafish showed close linkage of the DAA and DAB loci on chromosome 8, but lack of other genes residing in the human MHC region [ 14].

BMC Genomics

Expert writing Tips

Best practice

When using "in close linkage", ensure the context clearly establishes the elements being connected. Specify what aspects are linked to avoid ambiguity.

Common error

Avoid using "in close linkage" when the connection is weak or indirect. Using phrases like "loosely related" or "tangentially connected" are more appropriate for less direct relationships.

Linguistic Context

The phrase "in close linkage" functions as a prepositional phrase, often used to modify a noun or clause by indicating a strong connection or association. As Ludwig AI confirms, the usage is valid and commonly found in technical writing.

Expression frequency: Uncommon

Frequent in

Science

90%

News & Media

10%

Formal & Business

0%

Less common in

Encyclopedias

0%

Wiki

0%

Reference

0%

Ludwig's WRAP-UP

In summary, the phrase "in close linkage" is a grammatically correct and valid phrase used to describe a strong connection or association between elements, especially in technical and scientific contexts. As Ludwig AI indicates, it's more common in formal settings and its best practices include ensuring clarity about the connected elements. While alternatives like "closely linked" or "strongly associated" exist, the specific context should guide the choice. Overall, the phrase serves to highlight significant relationships, especially in academic and scientific writing.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

closely linked

Focuses more on the state of being linked, omitting the preposition "in".

tightly connected

Emphasizes the strength of the connection, rather than the concept of linkage.

strongly associated

Highlights the association between elements, diverging slightly from direct linkage.

intimately related

Suggests a deep and personal relationship, which might not always be applicable.

in tight association

Uses "association" instead of "linkage", slightly shifting the technical connotation.

in close correlation

Implies a statistical relationship, which may not be appropriate in all contexts.

in direct relationship

Highlights the directness of the connection, potentially excluding indirect links.

intertwined

Suggests a complex and interwoven connection, differing from simple linkage.

inseparable

Implies a bond that cannot be broken, a stronger statement than close linkage.

in conjunction

Suggests elements that acting together rather than a relationship.

FAQs

What does "in close linkage" mean in genetics?

In genetics, "in close linkage" refers to genes or DNA sequences that are located near each other on the same chromosome. Due to their proximity, they tend to be inherited together during meiosis.

How can I use "in close linkage" in a sentence?

You can use "in close linkage" to describe a strong relationship or association between two or more things. For example: "The study found that these two genes are "in close linkage", suggesting they may influence the same trait."

What are some alternatives to saying "in close linkage"?

Alternatives to "in close linkage" include "closely linked", "tightly connected", or "strongly associated". The best choice depends on the specific context and the nuance you wish to convey.

Is there a difference between "in close linkage" and "in close proximity"?

"In close linkage" often implies a functional or genetic relationship, whereas "in close proximity" simply indicates nearness in space or time. They are not always interchangeable.