highly substantial

USAGE SUMMARY

The phrase "highly substantial" is correct and usable in written English.
It can be used to emphasize the significant nature or importance of something. Example: "The research findings provide highly substantial evidence to support the new theory."

✓ Grammatically correct

Science

News & Media

Wiki

Human-verified examples from authoritative sources

Exact Expressions

7 human-written examples

PREEMPT supports the efficacy and tolerability of onabotulinumtoxinA for the prophylaxis of headache in adults with CM.[1] These data demonstrate that onabotulinumtoxinA treatment results in a significant 75% reduction in multiple headache symptom measures and highly substantial efficacy for a subpopulation of patients studied.

The Journal of Headache and Pain

However, once this volume is reached the effects were highly substantial.

British Journal of Sports Medicine

Regarding CSME, κ was 0.73 (SE = 0.061) for grader 1 and 0.77 (SE = 0.056) for grader 2, which means a highly substantial agreement between the imaging methods.

Diabetes Care

Influence of the RS on the change rate was highly substantial if patients with initial recommendation for chemotherapy or hormonal therapy were considered separately (P < 0.001 for both).

Annals of Oncology

κ for grader 1 was 0.792 (SE = 0.039) and 0.774 (SE = 0.039) for grader 2, indicating a highly substantial agreement between the imaging methods.

Diabetes Care

A highly substantial agreement between both Optomap DR and CSME grading and ETDRS 7-field photography existed with κ = 0.79 for DR and 0.73 for CSME for grader 1, and κ = 0.77 (DR) and 0.77 (CSME) for grader 2. Determination of CSME and grading of DR level from Optomap Panoramic 200 nonmydriatic images show a positive correlation with mydriatic ETDRS 7-field stereo photography.

Diabetes Care

Human-verified similar examples from authoritative sources

Similar Expressions

53 human-written examples

Furthermore, for this subgroup both the fixed effect and random effects estimates suggest a highly Significant and substantial detrimental effect of neoadjuvant chemotherapy.

BMC Medical Research Methodology

This notion was reinforced by the substantial, highly significant deficit of nonsense mutations in both EST collections compared to the neutral expectation (Table 1).

BMC Cancer

There were substantial highly significant raised risks in Indian ethnic migrants for cancers of the mouth and pharynx, gall bladder, and liver in each sex, larynx and thyroid in males, and oesophagus in females.

British Journal of Cancer

The v-fos FBJ murine osteosarcoma viral oncogene homolog gene (FOS) displayed an expression profile that showed highly significant and substantial decreases – again, in a coordinated fashion – between the N'Dama and Boran groups, which were particularly apparent from 21 dpi onwards relative to pre-infection levels.

BMC Genomics

We show that this measurement of sunlight correlates with actual exposure, and consistent with pre-existing results from the fetal development literature, we find substantial and highly significant evidence in both datasets that increased sunlight during the second trimester lowers the subsequent probability of asthma.

Harvard University

Expert writing Tips

Best practice

When using "highly substantial", ensure that the context warrants a strong emphasis on the magnitude or significance of the subject. Overuse can dilute its impact.

Common error

Avoid using "highly substantial" when the context requires a description of quality rather than quantity or scale. The phrase is best suited for emphasizing size, amount, or impact rather than inherent attributes.

Linguistic Context

The phrase "highly substantial" functions as an intensifying adjective phrase, modifying nouns to indicate something is of considerable importance or size. It emphasizes the degree to which something is significant, aligning with Ludwig AI's assessment of correctness and usability.

Expression frequency: Uncommon

Frequent in

Science

71%

News & Media

21%

Wiki

7%

Less common in

Formal & Business

0%

Encyclopedias

0%

Reference

0%

Ludwig's WRAP-UP

In summary, "highly substantial" is a grammatically sound and usable phrase that emphasizes the significant size, impact, or importance of a subject. As Ludwig AI confirms, it is suitable for formal contexts, particularly in scientific and news domains. While not exceedingly common, the phrase effectively conveys emphasis when used judiciously. Remember to use "highly substantial" when you want to underscore the magnitude or importance of something, ensuring that the context warrants such emphasis. Consider alternatives like "extremely significant" or "very considerable" when a slightly different nuance is desired. Be aware of its primary function in formal settings to avoid misapplication in casual contexts.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

extremely significant

Replaces "substantial" with "significant" and "highly" with "extremely", altering emphasis.

particularly significant

Emphasizes significance using "particularly", which gives a more specific focus.

greatly significant

Uses "greatly" to intensify the significance.

very considerable

Substitutes "substantial" with "considerable" and "highly" with "very", softening the tone slightly.

considerably important

Highlights importance in a way that suggests thoughtful consideration.

markedly significant

Replaces "highly" with "markedly", giving a different nuance to the level of significance.

notably important

Replaces "substantial" with "important" and "highly" with "notably", indicating clear noteworthiness.

exceptionally large

Shifts focus to size rather than general importance, using "large" instead of "substantial".

remarkably large

Combines the idea of being noteworthy and of considerable size.

extraordinarily large

Conveys that something is beyond the ordinary in its size or impact.

FAQs

How can I use "highly substantial" in a sentence?

Use "highly substantial" to describe something of great significance or considerable size. For example: "The research findings provide "highly substantial" evidence to support the new theory".

What are some alternatives to "highly substantial"?

You can use alternatives like "extremely significant", "very considerable", or "markedly significant" depending on the context.

Is it correct to say "substantial highly" instead of "highly substantial"?

While not grammatically incorrect, "highly substantial" is the more conventional and commonly used order. Reversing the order might sound awkward to native English speakers. You should prefer "highly substantial".

What's the difference between "highly substantial" and "very significant"?

"Highly substantial" often implies a greater magnitude or impact compared to "very significant". "Highly substantial" is often used when referring to tangible quantities or results, whereas "very significant" can apply more broadly to abstract concepts or implications.