During the asymmetric divisions of Drosophila male GSCs [2] and larval neuroblasts (NBs) [1, 3] the two centrosomes behave asymmetrically, and in male GSCs, it has been shown that a centrosome's behavior depends on its mother-daughter identity.
Although live imaging would be required to fully describe centrosome movements in female GSCs, it appears that the centrosomes do not behave in the manner observed in male GSCs and NBs.
We demonstrated that another feature of GSCs is the upregulation of ST3GalIII, which is involved in the de novo synthesis of carbohydrate antigens on different glycoproteins, and in GSCs it could be responsible for an altered pattern of glycosylation, already previously described.
Depletion of Chd had stronger effects than Gsc, for it was epistatic to Vent1/2 (Supplementary Figure 7).
As clonal expansion entails more GSC replication, it is anticipated that this process would result in further telomere elongation, based on the premise that telomerase 'overshoots' with each replication of male GSCs.
This raises the possibility that our own vaccination strategy enriched GSCs because it failed to include T cell epitopes of GSCs.
86 Surface nestin was originally identified in murine glioma stem cells (GSCs) and it was reported as a ∼60-kDa N-terminal isotype of nestin.
