Sentence examples for sgc it from inspiring English sources

Although NO triggers several phosphorylation cascades due to its ability to react with Fe II in heme-containing proteins such as sGC, it also promotes a selective posttranslational modification in cysteine residues by S-nitrosylation, impacting on protein function, stability, and allocation.

With regard to these adaptive effects of sGC it may be speculated that the delayed excitatory actions of NO donor infusion, i.e. delayed headaches [24] and increase in neuronal activity [30] and c-fos activation [45] in the spinal trigeminal nucleus, is not dependent on a sGC-mediated effect of NO.

GCY-35 is required by C. elegans for avoiding hyperoxic conditions and unlike canonical NO-sensitive sGCs, it can bind oxygen [ 29].

Since Id3 was also expressed in these cells and may play a role in the proliferative and/or invasive phenotype of SGCs, it is possible that a double Id1/Id3 knockdown would further increase the reduction of tumor cell aggressiveness.

By placing the SmartRock sensor at different locations within a SGC mold, it was found that the particle located at mid-depth layer received more effective compaction as compared to the particle located at the bottom.

While the study was intended to study heterodimerization of sGC subunits, it is interesting to compare the results using BiFC with regard to the structural organization of sGC to our FRET approach.

The large heterodimeric structure of sGC makes it particularly challenging to detect binding of low molecular weight compounds using SPR.

Regardless, our structure is the closest to that of the catalytic domains in full-length sGC, as it is heterodimeric and devoid of mutations.

In this section, I discuss the syntactic position and syntactic function of TAc in a SGC, showing that it is the subject of the secondary predicate.

Therefore, drugs that are able to activate the NO-insensitive form of sGC thus reactivating it might have cardioprotective effects in various pathological conditions through the enhancement of the impaired cGMP-signalling.

The short time frame of the experiments excludes up-regulation of sGC expression, but it is conceivable that l-NNA blocked inactivation of NO by superoxide, which may be generated by uncoupled NO synthase in GTN-exposed blood vessels [39].