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All consecutive, eligible patients who fulfil selection criteria will be offered study participation.
Potential participants will undergo telephone screening followed by clinical examination by a physiotherapist or medical practitioner and a podiatrist to ensure they fulfil selection criteria.
As of 18 December 2014, out of 368 women approached, 176 did not fulfil selection criteria, 85 declined participation and 107 consented to participate in the study.
Two independent researchers (PK and SCS) will then screen titles and abstracts of remaining references, and perform full-text review as necessary to identify those studies that fulfil selection criteria.
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Inclusion process Two authors (NAMC and TJC) independently reviewed the titles and abstracts from the electronic literature searches and selected citations if they seemed to fulfil the selection criteria.
Papers that did not fulfil the selection criteria were excluded.
Participants Of 892 patients screened, 582 were randomised, while 289 did not fulfil the selection criteria and 21 withdrew consent.
Specificity is the proportion of noncarriers who do not fulfil the selection criteria (below the cutoff level).
All eligible patients who fulfil the selection criteria during the recruiting period will be invited to participate.
The positive predictive value is the proportion of individuals who fulfil the selection criteria and who carry a BRCA mutation.
Potential recruits will be asked if they fulfil the selection criteria and canvassed about their willingness to join in the study.
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