first generation compounds

USAGE SUMMARY

The phrase "first generation compounds" is correct and usable in written English.
It can be used in scientific or technical contexts, particularly in chemistry or pharmacology, to refer to compounds that are the initial versions or earliest forms of a particular class of substances. Example: "The study focused on first generation compounds to evaluate their efficacy before moving on to more advanced formulations."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

4 human-written examples

While HDACi have demonstrated therapeutic utility, many of the first generation compounds are pan-inhibitors.

Life Sciences

However, MB is the first generation compounds and is not selective for HSP70.

BioMed Research International

The second generation Spm analogue N -ethyl-N -(cyclopropyl)-methyl-4,8-diazaundecane (CPENSpm) [ 16] has demonstrated lower toxicity and greater therapeutic efficacy than the first generation compounds.

BMC Cancer

This was achieved by engineering long hydrophobic side chains to the backbone polymer, which maximize hydrophobic interactions with bile acids, adding to the effects of the ionic bonds that bind bile acids in the two first generation compounds.

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Human-verified similar examples from authoritative sources

Similar Expressions

56 human-written examples

This change led to a second generation compound with increased potency, a 400-fold enhancement in aqueous solubility at pH 4, and improved dog pharmacokinetics relative to the first generation compound.

Bioorganic & Medicinal Chemistry Letters

The suitable furan diene was obtained by modifying a methacrylate polymer by its reaction with furfural, a first generation compound derived from renewable resources.

European Polymer Journal

PTC124 and NB54 resulted in the similar significant increase in read-through (8.0-fold and 7.9-fold, respectively) followed by a 7.2-fold increase by NB30, the first generation compound (Fig 4B, Table 1).

EMBO Molecular Medicine

Features are scored for statistical significance and can be utilized to design improved second generation compounds or more target-focused libraries.

Bioorganic & Medicinal Chemistry Letters

A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa.

Bioorganic & Medicinal Chemistry Letters

Currently, these inhibitors are pre-clinical compounds; however, there is significant increase in the development of second generation compounds that could be tested in a phase I or II trials.

Clinical and Translational Medicine

Many of the first and second generation compounds, like JWH-018 or JWH-007, bare Huffman's initials.

Vice

Expert writing Tips

Best practice

When discussing improvements over older formulations, clearly state the specific limitations of the "first generation compounds" that the newer versions address, such as reduced side effects or increased efficacy.

Common error

Avoid assuming that all "first generation compounds" within a class share the same drawbacks. Specific compounds may have unique properties or fewer side effects than others in the same generation.

Linguistic Context

The phrase "first generation compounds" functions primarily as a noun phrase, acting as a subject or object within a sentence. It denotes a specific category of chemical substances that represent the initial versions of their kind. Ludwig AI confirms its usability in written English.

Expression frequency: Uncommon

Frequent in

Science

100%

News & Media

0%

Formal & Business

0%

Less common in

Encyclopedias

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Wiki

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Reference

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Ludwig's WRAP-UP

The phrase "first generation compounds" is a noun phrase used to identify the earliest versions of chemical substances. Ludwig AI validates its correctness and usability, especially within scientific and technical writing. Usage is generally formal, occurring predominantly in scientific literature. Related phrases include "early generation compounds" and "initial generation compounds". When using this phrase, be specific about the limitations you're addressing and avoid overgeneralizing drawbacks. The context is usually scientific, as it's often used to differentiate earlier compounds from later, improved versions.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

early generation compounds

Replaces "first" with "early", emphasizing the temporal aspect of being among the initial compounds developed.

initial generation compounds

Uses "initial" instead of "first" to convey the same meaning of being the starting point.

original compounds

Focuses on the compounds being the originals or prototypes in a series.

prototype compounds

Highlights the compounds as being the initial models or prototypes.

first wave compounds

Metaphorically describes the compounds as part of the first wave or group introduced.

legacy compounds

Implies these compounds are older and possibly replaced by newer versions.

first-generation agents

Substitutes "compounds" with "agents", a broader term for active substances.

early versions of compounds

Expands on the concept to clarify that these are the earlier versions.

first series compounds

Refers to the compounds as part of the initial series or sequence.

foundational compounds

Emphasizes that these compounds laid the groundwork for later developments.

FAQs

How can I use "first generation compounds" in a sentence?

You can use "first generation compounds" to refer to the earliest versions of a particular type of chemical substance, such as "The study compared the efficacy of first generation compounds with that of more recent formulations."

What are some alternatives to "first generation compounds"?

Alternatives include "early generation compounds", "initial generation compounds", or "original compounds", depending on the specific context.

Are "first generation compounds" always inferior to later generations?

While later generations often have improvements, "first generation compounds" may still be preferred in certain situations due to factors like cost, availability, or specific therapeutic effects.

What is the difference between "first generation compounds" and "second generation compounds"?

"First generation compounds" refers to the initial versions, while "second generation compounds" indicates subsequent formulations, typically designed to improve upon the originals in terms of efficacy, safety, or other properties.