Sentence examples for early generation compounds from inspiring English sources

Although the affinities of the early generation sphingosine kinase inhibitors are 2 3 log orders lower than would be expected of an enzyme inhibitor developed by the pharmaceutical industry, two early generation compounds are in clinical trials for oncology indications.

FRAX1036 is devoid of the characteristic arylamino moiety of earlier generation compounds, resulting in improved kinase selectivity (Additional file 2: Table S1) and general drug properties.

Early generation examples of this type of compound (wortmannin and LY294002 which inhibit the catalytic activity of p110) have been studied extensively in in vitro assays.

The early generation of Pentecostals was accustomed to worse.

Early generation lenses like SoftPerm have been discontinued.

Many of the first and second generation compounds, like JWH-018 or JWH-007, bare Huffman's initials.

Early generations are usually wingless, but by the third generation winged individuals appear.

There are now third- and fourth- generation compound residents, their technical expertise still crucial to extracting oil.

The user can delegate several early generations to the system.

They often also concern the early generations of evolutionists.

Importantly, both TH-302 and PR-104 display pre-clinical activity when used as single agents, which sets these compounds apart from earlier generation hypoxia-activated cytotoxins (such as TPZ) which demonstrate anti-tumour activity only when used in combination with radiation or chemotherapy.