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That occurs because of the evident human (biotic) features of divergence from routine reasoning and calculus, use of intuition and other intriguing biotic generic cognitive behaviours (introducing analogies, abstractions, relations, boundaries, equalities, consistencies, and beauties into the expert and domain-dependent reasoning) (Hofstadter 1995).
We also quantified the relative amount of shared and unique features of divergence for each trait using multivariate analysis of covariance (MANCOVA) [ 39].
To quantify the relative amount of shared and unique features of divergence across the species complex, a MANCOVA analysis was performed according to the method in [ 39].
According to the findings obtained using curated pathway gene sets, the pathway involved in olfactory signalling and regulation is the least conserved since it has significant features of divergence for three of the parameters considered, indicating an increased functionality in the mouse (Fig. 3, Additional file 5).
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In this case, most features of sequence divergence – the prevalence of negative selection, rate asymmetry, and excessive numbers of non-synonymous substitutions – indicate that post-duplication sequence change has been functional.
However, if constraints explain the origin of all the features of the divergence angle phenomenon, it would no longer be an adaptation, since it was not shaped by natural selection.
In addition to an expansion in paralogs, adaptation features of genome divergence usually induce an excess of nonsynonymous over synonymous substitutions (dN > dS) at orthologous genes, which can be identified as positively selected genes (PSGs) by the likelihood ratio test and lineage-specific accelerated evolving gene ontology (GO) categories by the binominal test.
In contrast, tumors grown as xenografts from individual clones derived from ARMS cell lines showed all of the classical morphological features of ARMS suggesting divergence in vivo from precursor cells propagated in culture.
Too little is known about splice isoforms in the other species to draw strong conclusions from these data, but interesting features of conservation and divergence are apparent.
We resolved features of genome adaptive divergence from an increase in gene copy number, an increase in nonsynonymous (dN) over synonymous (dS) substitutions, and lineage-specific genes.
We further tested the prediction power of divergence features when combined with classical features computed on a 20 residue N-terminal instead of 40 (which might be too long for the SP class).
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Justyna Jupowicz-Kozak
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