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The tumor cells may show certain features of differentiation, but the cells are not equivalent to any specific differentiated cell-type, and seem to occupy a primitive developmental state that precedes the development of embryonic layers.
Differentiation induction by BAY 2402234 treatment was further confirmed by Giemsa-Wright stainings for morphologic features of differentiation (Supplementary Fig. 2a) and by flow cytometry for CD14, another marker of myeloid differentiation (Supplementary Fig. 2b d).
We argue that a modular architecture comprising repeated network elements reproduces these features of differentiation by sequentially repressing selected modules and hence restricting the dynamics to lower dimensional subspaces of the high-dimensional state space.
Moreover it takes at least 10 days until typical features of differentiation are up-regulated.
SW480 cells show less features of differentiation (e.g. enterocytic differentiation, cell polarity) than HT29 cells [59].
After the appearance of morphologic features of differentiation, cells were used for histochemical study.
Similar(39)
The epidermal differentiation complex (EDC) locus comprises a syntenic and linear cluster of genes whose concomitant expression is a hallmark feature of differentiation in the developing skin epidermis.
MR feature of differentiation between the mucosaesubmucosa complex and the muscularis propria also showed the similar pattern in our study.
A recent study found that NEAT1 might be a general feature of differentiation [ 62– 64], supporting our predicted function of cell differentiation.
Based on the overview of histone H3 clipping events, we agree with the notion that H3 clipping could well represent a common feature of differentiation 90.
These results indicate dynamic changes in DNA methylation during development and that epigenetic changes resulting in unmethylated DS-DMRs are a major feature of differentiation into adult tissues.
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